In vitro and In vivo Models used for Drug discovery and Drug screening on Atherosclerotic Research: a Review

Abstract

The processes behind atherosclerosis, the largest cause of mortality globally, are largely unknown. Nonetheless, several in vitro and in vivo models have considerably enhanced our insight into the processes behind atherosclerosis and enabled the assessment of potential treatment interventions. This article will examine the in vivo and in vitro models used to investigate atherosclerosis. High Cholesterol feed (HCF) conception and mechanical endothelial dysfunctions are the main characteristics found in the majority of atherosclerosis models. Despite the lack of a single in vivo model that completely replicates the progression of atherosclerosis in humans, there are several promising animal models. In addition, with the arrival of gene-modified animals, these models considerably broaden our understanding of the progression of atherosclerosis.