Effect of Lactobacillus rhamnosus and Diclofenac with Curcumin for neuronal restoration and repair against Scopolamine induced Dementia in Zebrafish (Danio rerio)

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Enzyme Inhibition Pub Date : 2023-05-08 DOI:10.2174/1573408019666230508155702

Sonali Pande, Chirag Patel

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引用次数: 0

Abstract

Clinical studies have already revealed the ubiquitous neuroprotective role of curcumin in neuronal deterioration, but it cannot be used alone due to its truncated bioavailability. Currently, many such approaches are functional, which overcome this issue either by increasing the solubility or absorption. These approaches carry a costlier treatment. One more tactic is present but less focused i.e., by limiting the intestine and liver enzymatic metabolism; by this approach, curcumin will be more available for its beneficial outcome. The goal of this study was to evaluate the impact of Lactobacillus rhamnosus and diclofenac on the neuroprotective effects of curcumin against scopolamine-induced dementia. Physical parameters involved a novel tank test, T maze test, whereas neurochemical parameters include brain oxidative stress and acetylcholinesterase (Ache) inhibition activity in a zebrafish dementia model. Our results demonstrated that curcumin with Lactobacillus rhamnosus and diclofenac significantly (p<0.05) reduced anxiety, memory deficits, and brain oxidative stress compared to the alone curcumin-treated group. This result approves that curcumin with L.rhamnosus and diclofenac have superior activity compared to curcumin alone. However, further clinical studies are needed to validate these findings

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鼠李糖乳杆菌、双氯芬酸联合姜黄素对东莨菪碱致痴呆斑马鱼神经元恢复和修复的影响

临床研究已经揭示了姜黄素在神经元退化中普遍存在的神经保护作用，但由于其生物利用度被截断，不能单独使用。目前，许多这样的方法都是功能性的，它们通过增加溶解度或吸收来克服这个问题。这些方法的治疗成本更高。另一种策略是存在的，但不太集中，即通过限制肠道和肝脏的酶代谢;通过这种方法，姜黄素将更容易获得其有益的结果。本研究的目的是评估鼠李糖乳杆菌和双氯芬酸对姜黄素对东莨菪碱诱导的痴呆的神经保护作用的影响。在斑马鱼痴呆模型中，物理参数包括一种新颖的坦克测试，T迷宫测试，而神经化学参数包括脑氧化应激和乙酰胆碱酯酶(Ache)抑制活性。我们的研究结果表明，姜黄素与鼠李糖乳杆菌和双氯芬酸相比，单独姜黄素治疗组显著(p<0.05)减少了焦虑、记忆缺陷和脑氧化应激。结果表明，与单用姜黄素相比，与鼠李糖和双氯芬酸联用的姜黄素具有较好的活性。然而，需要进一步的临床研究来验证这些发现

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来源期刊

Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.