Hunger Hormones in Disruptive Mood Dysregulation Disorder in Adolescents: An Exploratory Study

IF 0.4 Q4 PEDIATRICS

Adolescent Psychiatry Pub Date : 2022-04-15 DOI:10.2174/2210676612666220415112851

A. Krishna, N. Goyal, D. Ram, Anjanik Kumar Rajan, K. K. Kshitiz

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引用次数: 0

Abstract

Hunger hormones, including ghrelin and leptin, are associated with appetitive behaviors in various psychiatric disorders. Biochemical and hormonal status in disruptive mood dysregulation disorder (DMDD) in adolescents is largely unexplored. The study aimed to assess levels of leptin and ghrelin and find their association with lipid profiles in adolescents with DMDD. Twenty adolescents with a DSM 5 diagnosis of DMDD with age and gender-matched 19 healthy controls were recruited, followed by clinical assessment. They were assessed for leptin, ghrelin, and lipid profiles, respectively. Adolescents with DMDD were comparable in age, education, family income, domicile status, psychiatric illness in the family, and body mass index (BMI) with matched controls. There was no difference in mean lipid profile and ghrelin in both groups. However, the DMDD group had statistically significant higher mean level of leptin as compared to the control group (t=1.84, p < 0.05). As measured by the Modified Overt Aggression Scale in DMDD, aggression showed a significant positive correlation with measures of lipid profile. Adolescents with DMDD have elevated serum leptin levels. Further research is needed to confirm this finding.

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青少年破坏性情绪调节障碍中的饥饿激素：一项探索性研究

饥饿激素，包括胃饥饿素和瘦素，与各种精神疾病的食欲行为有关。青少年破坏性情绪调节障碍（DMDD）的生化和激素状态在很大程度上尚未被探索。该研究旨在评估青少年DMDD患者的瘦素和胃饥饿素水平，并发现它们与脂质状况的关系。招募了20名年龄和性别匹配的DSM 5诊断为DMDD的青少年19名健康对照，随后进行临床评估。分别评估了它们的瘦素、胃饥饿素和脂质状况。患有DMDD的青少年在年龄、教育程度、家庭收入、户籍状况、家庭精神疾病和体重指数（BMI）方面与匹配的对照组具有可比性。两组的平均脂质水平和胃饥饿素水平没有差异。然而，与对照组相比，DMDD组的瘦素平均水平具有统计学意义（t=1.84，p<0.05）。根据DMDD的改良显性攻击量表测量，攻击性与脂质水平呈正相关。患有DMDD的青少年血清瘦素水平升高。需要进一步的研究来证实这一发现。

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来源期刊

Adolescent Psychiatry PEDIATRICS-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Adolescent Psychiatry a peer-reviewed journal, aims to provide mental health professionals who work with adolescents with current information relevant to the diagnosis and treatment of psychiatric disorders in adolescents. Adolescent Psychiatry reports of original research, critical reviews of topics relevant to practitioners, clinical observations with analysis and discussion, analysis of philosophical, ethical or social aspects of the fields of psychiatry and mental health, case reports with discussions, letters, and position papers. Topics include adolescent development and developmental psychopathology, psychotherapy and other psychosocial treatment approaches, psychopharmacology, and service settings and programs. The primary focus of the work should be on adolescents, transition-aged youth, The primary focus of the work should be on adolescents, transition-aged youth, or emerging adults, that is, persons 12-24 years of age . Articles on families of adolescents, or adults who have been followed since adolescence will also be considered.