Effects of tetracycline and clotrimazole ointments in the treatment of palmar arsenical keratosis

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2020-03-08 DOI:10.3329/bjp.v15i1.45249

A. Ferdous, M. Misbahuddin, Abu Naser Ibne Sattar

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Abstract

The study was designed to see the effects of tetracycline and clotrimazole on the altered skin flora (Aspergillus and Enterobacter species) in 38 patients with palmar arsenical keratosis. The skin swab and scrapping samples were collected. Tetracycline, clotrimazole and their combination were given as ointment for 3 months. Clotrimazole and tetracycline were found to inhibit the growth of Aspergillus spp. and Enterobacter spp. in vitro. A pH-dependent inhibition of the growth of microorganisms in presence of these antimicrobials was observed, which was highest at pH 8. The percentage reduction of keratotic nodular size was 32.9, 66.1, 61.1 and 32.5 in the groups treated with placebo, tetracycline, clotrimazole and the combination of both, respectively. But none of the interventions was proved statistically significant. No remarkable adverse effect was reported. In conclusion, clotrimazole or tetracycline inhibits the growth of Aspergillus spp. or Enterobacter spp. in vitro. However, there was no statistically significant clinical improvement of the palmar arsenical keratosis.

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四环素联合克霉唑软膏治疗手掌砷性角化病的疗效观察

本研究旨在观察四环素和克霉唑对38例掌砷性角化病患者皮肤菌群(曲霉和肠杆菌)改变的影响。采集皮肤拭子和刮擦样本。四环素、克霉唑及其联合软膏给予3个月。氯霉唑和四环素对体外培养的曲霉和肠杆菌有抑制作用。在这些抗菌剂的存在下，观察到微生物生长的pH依赖性抑制，其在pH 8时最高。在安慰剂组、四环素组、克霉唑组和两者联合治疗组，角化性结节大小减少的百分比分别为32.9、66.1、61.1和32.5。但没有一项干预被证明具有统计学意义。未见明显不良反应。综上所述，氯霉唑和四环素在体外均能抑制曲霉和肠杆菌的生长。然而，掌砷性角化病的临床改善无统计学意义。

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.