Electrospun PCL/PVA Coaxial Nanofibers with Embedded Titanium Dioxide and Magnetic Nanoparticles for Stabilization and Controlled Release of Dithranol for Therapy of Psoriasis

IF 2.6 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Magnetochemistry Pub Date : 2023-07-19 DOI:10.3390/magnetochemistry9070187

Natália Andrýsková, P. Sourivong, M. Babincová, P. Babinec, M. Šimaljaková

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引用次数: 0

Abstract

Dithranol is one of the oldest and most efficient drugs used in the treatment of psoriasis. One of the challenges with using dithranol is its photostability, because it easily degrades when exposed to light. This study investigated the potential of coaxial core-sheath PCL/PVA nanofibers as a dual-functional system for enhancing dithranol photostability and remote-controlled drug delivery for psoriasis therapy. We have shown that coaxial nanofibers with titanium oxide nanoparticles (reflecting and absorbing ultra-violet light) in the PVA-based sheath part of the nanofibers can increase dithranol photostability. Incorporation of dithranol and magnetic nanoparticles into a PCL-based core of the nanofibers enables dithranol release control via an external radio-frequency field. The application of a radio-frequency field generates heat that can be used to control the release rate of drugs. Our approach therefore offers a non-invasive and remotely controlled drug release system that hold promise for the development of new topical formulations for psoriasis treatment using dithranol.

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电纺PCL/PVA同轴纳米纤维与嵌入的二氧化钛和磁性纳米颗粒用于稳定和控制释放二氢大麻酚治疗银屑病

二氢大麻酚是治疗银屑病最古老、最有效的药物之一。使用双萘酚的挑战之一是其光稳定性，因为它在暴露于光下时很容易降解。本研究探讨了同轴芯鞘PCL/PVA纳米纤维作为一种双功能系统在增强双萘酚光稳定性和远程控制药物递送治疗银屑病方面的潜力。我们已经表明，在纳米纤维的PVA基鞘部分中具有氧化钛纳米颗粒（反射和吸收紫外线）的同轴纳米纤维可以提高双萘酚的光稳定性。将双萘酚和磁性纳米颗粒掺入基于PCL的纳米纤维芯中，可以通过外部射频场控制双萘酚的释放。射频场的应用产生的热量可用于控制药物的释放速率。因此，我们的方法提供了一种非侵入性和远程控制的药物释放系统，有望开发使用双萘酚治疗银屑病的新局部制剂。

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来源期刊

Magnetochemistry Chemistry-Chemistry (miscellaneous)

CiteScore

3.90

自引率

11.10%

发文量

145

审稿时长

11 weeks

期刊介绍： Magnetochemistry (ISSN 2312-7481) is a unique international, scientific open access journal on molecular magnetism, the relationship between chemical structure and magnetism and magnetic materials. Magnetochemistry publishes research articles, short communications and reviews. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.