Isolated paracetamol-induced acute kidney injury: a systematic review.

Q3 Medicine

Acute Medicine Pub Date : 2022-04-01 DOI:10.52964/AMJA.0904

M. Williams, J. Coulson

引用次数: 0

Abstract

AIM We sought to characterise the syndrome of isolated paracetamol-induced acute kidney injury (AKI), whose incidence and mechanisms are poorly understood. METHODS Using systematic review methodology, fifty-six papers relating to paracetamol-induced AKI were identified. RESULTS 24 cases of isolated paracetamol-induced AKI were identified and compared to 87 identified cases of concurrent renal and hepatic injury. Paracetamol-induced AKI became detectable 3-4 days after exposure; liver injury, where it occurred, preceded AKI detection by 1 day. Risk factors affecting hepatotoxicity risk do not appear to influence isolated AKI, with no clear associated factors except younger age (mean 18.8 versus 33.1 years). CONCLUSIONS Isolated paracetamol-induced AKI appears commoner in younger patients. Paracetamol-induced AKI occurs late and may go undetected by current treatment guidelines.

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对乙酰氨基酚引起的急性肾损伤：一项系统综述。

目的我们试图描述单独的扑热息痛诱导的急性肾损伤（AKI）的综合征，其发病率和机制尚不清楚。方法采用系统综述的方法，对56篇与扑热息痛诱导的AKI相关的论文进行了鉴定。结果24例分离的对乙酰氨基酚诱导的AKI病例被鉴定，并与87例已鉴定的并发肾和肝损伤病例进行了比较。对乙酰氨基酚诱导的AKI在暴露3-4天后可检测到；发生肝损伤的地方，在AKI检测之前1天。影响肝毒性风险的危险因素似乎不会影响孤立的AKI，除了年龄较小（平均18.8岁对33.1岁）外，没有明确的相关因素。结论：孤立的对乙酰氨基酚诱导的AKI在年轻患者中更常见。对乙酰氨基酚诱导的AKI发生较晚，目前的治疗指南可能未发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acute Medicine Medicine-Emergency Medicine

CiteScore

1.50

自引率

0.00%

发文量

期刊介绍： These are usually commissioned by the editorial team in accordance with a cycle running over several years. Authors wishing to submit a review relevant to Acute Medicine are advised to contact the editor before writing this. Unsolicited review articles received for consideration may be included if the subject matter is considered of interest to the readership, provided the topic has not already been covered in a recent edition. Review articles are usually 3000-5000 words and may include tables, pictures and other figures as required for the text. Include 3 or 4 ‘key points’ summarising the main teaching messages.