The comparison of antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic effects of Fe@Au nanosphere magnetic nanoparticles

IF 1.1 4区生物学 Q3 BIOLOGY

Turkish Journal of Biology Pub Date : 2017-04-01 DOI:10.3906/biy-1607-2

Hande Yeğenoğlu, B. Aslim, Burcu Guven, A. Zengin, I. Boyaci, Z. Suludere, U. Tamer

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引用次数: 2

Abstract

Magnetic gold nanoparticles are used in various biomedical, biochemistry, and biotechnology applications due to their controllable size distribution, long-term stability, reduced toxicity, and biocompatibility. Different coating materials, such as proteins, carbohydrates, lipids, and polyphenols, are applied to enhance the biocompatibility of nanoparticles. In this study, the effects of surface coatings of core-shell structured Fe@Au nanosphere magnetic nanoparticles with regard to antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic properties were investigated. The obtained results demonstrated that avidin-coated Fe@Au nanospheres had higher antioxidant capacities than uncoated nanospheres. Neither avidin-coated nor uncoated nanoparticles had a cytotoxic effect on normal cells (human gingival fibroblast cell line, HGF-1). In addition, they had anticarcinogenic effects on human cervical carcinoma (HeLa), human breast adenocarcinoma (MCF-7), and human colorectal adenocarcinoma (CCL-221). The genotoxic effects of nanoparticles were also evaluated with DNA tail damage ratio.

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Fe@Au纳米球形磁性纳米颗粒的抗氧化能力、细胞毒性、抗癌和基因毒性作用的比较

磁性金纳米颗粒由于其可控的尺寸分布、长期稳定性、低毒性和生物相容性，被用于各种生物医学、生物化学和生物技术应用。应用不同的涂层材料，如蛋白质、碳水化合物、脂质和多酚，以增强纳米颗粒的生物相容性。在本研究中，核壳结构的表面涂层的影响Fe@Au研究了纳米球磁性纳米颗粒的抗氧化能力以及细胞毒性、抗癌和基因毒性特性。所获得的结果表明Fe@Au纳米球比未涂覆的纳米球具有更高的抗氧化能力。抗生物素包被或未包被的纳米颗粒对正常细胞（人牙龈成纤维细胞系，HGF-1）都没有细胞毒性作用。此外，它们对人类宫颈癌（HeLa）、人类乳腺腺癌（MCF-7）和人类结直肠癌（CCL-221）具有抗癌作用。还用DNA尾部损伤率评价了纳米颗粒的遗传毒性作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish Journal of Biology BIOLOGY-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Turkish Journal of Biology is published electronically 6 times a year by the Scientific and Technological Research Council of Turkey (TÜBİTAK) and accepts English-language manuscripts concerning all kinds of biological processes including biochemistry and biosynthesis, physiology and metabolism, molecular genetics, molecular biology, genomics, proteomics, molecular farming, biotechnology/genetic transformation, nanobiotechnology, bioinformatics and systems biology, cell and developmental biology, stem cell biology, and reproductive biology. Contribution is open to researchers of all nationalities.