How Can Oncoplastic Breast Surgery Contribute to the Management of Locally Advanced Breast Cancer in Sub-Saharan Africa?

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2023-10-01 Epub Date: 2023-05-23 DOI:10.1159/000531151

Omar Abdul Hameed Ali, Ahmed Elhaj

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引用次数: 0

Abstract

Background: Because of resource constrains in sub-Saharan African countries, breast-conserving surgery (BCS) has no role in patients with locally advanced breast cancer (LABC) following neoadjuvant chemotherapy (NACT), and mastectomy remains the standard surgical treatment for these patients.

Objectives: The first objective of the study was to assess the safety of oncoplastic BCS in patients with LABC who showed good clinical response to NACT in a breast center with enhanced level of resources in Sudan. The second objective was to assess the cosmetic outcome.

Patients and methods: Two hundred and fifty patients with LABC were treated with NACT at Khartoum Breast Care Center during the period 2013-2019. Out of this, 52 patients were surgically treated with oncoplastic breast-conserving surgery. Kaplan-Meier curve was used to calculate the survival rates. The cosmetic outcome was subjectively assessed by the Harris scale.

Results: The median follow-up period was 53 months. The 3- and 5-years distant metastasis-free survival rates were 92.9% and 82.2%, respectively. One patient developed regional recurrence, and 6 patients developed distant metastasis. Eighty percentage of patients were admitted to have good to excellent cosmetic outcome.

Conclusion: This Sudanese experience showed that oncoplastic BCS is oncologically safe and aesthetically satisfactory in patients with LABC who demonstrated good clinical response to NACT in a setting with enhanced levels of resources for breast cancer care.

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肿瘤整形乳腺手术如何有助于撒哈拉以南非洲局部晚期癌症的管理？

背景：由于撒哈拉以南非洲国家的资源限制，在新辅助化疗（NACT）后局部晚期癌症（LABC）患者中，乳房切除术（BCS）没有任何作用，乳房切除术仍然是这些患者的标准手术治疗。目的：本研究的第一个目的是评估在苏丹资源水平提高的乳腺中心对NACT表现出良好临床反应的LABC患者使用肿瘤学BCS的安全性。第二个目的是评估美容效果。患者和方法：2013-2019年期间，250名LABC患者在喀土穆乳腺护理中心接受NACT治疗。其中，52名患者接受了肿瘤整形保乳手术治疗。Kaplan-Meier曲线用于计算生存率。美容效果通过Harris量表进行主观评估。结果：中位随访时间为53个月。3年和5年无远处转移生存率分别为92.9%和82.2%。1名患者出现区域复发，6名患者出现远处转移。百分之八十的患者接受了良好到卓越的美容效果。结论：苏丹的经验表明，对于在癌症护理资源水平提高的环境中对NACT表现出良好临床反应的LABC患者，肿瘤整形BCS在肿瘤学上是安全的，并且在美学上令人满意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.