Evaluation of miR-141-3p over-expression in ovarian cancer

IF 2.3 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Electronic Journal of Biotechnology Pub Date : 2022-07-01 DOI:10.1016/j.ejbt.2022.04.006

Lin Shi , Hao-Jia Sun , Jing-Jing Zeng , Zi-Qian Liang , Yun-Hua Lin , Su-Ning Huang , Jiang-Hui Zeng , Li Yang , Hao Chen , Jie Luo , Kang-Lai Wei

{"title":"Evaluation of miR-141-3p over-expression in ovarian cancer","authors":"Lin Shi , Hao-Jia Sun , Jing-Jing Zeng , Zi-Qian Liang , Yun-Hua Lin , Su-Ning Huang , Jiang-Hui Zeng , Li Yang , Hao Chen , Jie Luo , Kang-Lai Wei","doi":"10.1016/j.ejbt.2022.04.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The expression of miR-141-3p in many malignant tumors has been verified. Nevertheless, the relationship between ovarian cancer and miR-141-3p remains undetermined. Therefore, further exploration is required.</p></div><div><h3>Results</h3><p>According to data from 100 samples, the final results of RT-qPCR showed that miR-141-3p was highly expressed in ovarian cancer. Furthermore, miR-141-3p was able to distinguish ovarian cancer cells from ovary tissues. The most significant Kyoto Encyclopedia of Genes and Genomes pathway, was regulation of lipolysis in adipocytes in ovarian cancer. The expression of PIK3R1 was negatively correlated with miR-141- 3p. PIK3R1 has a combing site with miR-141-3p.</p></div><div><h3>Conclusions</h3><p>This study examined the expression levels and mechanism of miR-141-3p in ovarian cancer for the first time. The results suggested that miR-141-3p may promote the occurrence of ovarian cancer by down-regulating PIK3R1.</p><p><strong>How to cite:</strong> Shi L, Sun H-J, Zeng J-J, et al. Evaluation of miR-141-3p over-expression in ovarian cancer. Electron J Biotechnol 2022;58. https://doi.org/10.1016/j.ejbt.2022.04.006</p></div>","PeriodicalId":11529,"journal":{"name":"Electronic Journal of Biotechnology","volume":"58 ","pages":"Pages 14-24"},"PeriodicalIF":2.3000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0717345822000173/pdfft?md5=d2d49ce0b2037396953cc02d7dee69ea&pid=1-s2.0-S0717345822000173-main.pdf","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electronic Journal of Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0717345822000173","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 2

Abstract

Background

The expression of miR-141-3p in many malignant tumors has been verified. Nevertheless, the relationship between ovarian cancer and miR-141-3p remains undetermined. Therefore, further exploration is required.

Results

According to data from 100 samples, the final results of RT-qPCR showed that miR-141-3p was highly expressed in ovarian cancer. Furthermore, miR-141-3p was able to distinguish ovarian cancer cells from ovary tissues. The most significant Kyoto Encyclopedia of Genes and Genomes pathway, was regulation of lipolysis in adipocytes in ovarian cancer. The expression of PIK3R1 was negatively correlated with miR-141- 3p. PIK3R1 has a combing site with miR-141-3p.

Conclusions

This study examined the expression levels and mechanism of miR-141-3p in ovarian cancer for the first time. The results suggested that miR-141-3p may promote the occurrence of ovarian cancer by down-regulating PIK3R1.

How to cite: Shi L, Sun H-J, Zeng J-J, et al. Evaluation of miR-141-3p over-expression in ovarian cancer. Electron J Biotechnol 2022;58. https://doi.org/10.1016/j.ejbt.2022.04.006

Abstract Image

查看原文本刊更多论文

卵巢癌中miR-141-3p过表达的评价

miR-141-3p在许多恶性肿瘤中的表达已被证实。然而，卵巢癌与miR-141-3p之间的关系仍不确定。因此，需要进一步探索。结果根据100个样本的数据，RT-qPCR的最终结果显示miR-141-3p在卵巢癌中高表达。此外，miR-141-3p能够区分卵巢癌细胞和卵巢组织。《京都基因与基因组百科全书》中最重要的途径是卵巢癌中脂肪细胞的脂肪分解调控。PIK3R1的表达与miR-141- 3p呈负相关。PIK3R1与miR-141-3p有一个结合位点。结论本研究首次检测了miR-141-3p在卵巢癌中的表达水平及其机制。提示miR-141-3p可能通过下调PIK3R1促进卵巢癌的发生。引用方式:石磊，孙华军，曾建军，等。卵巢癌中miR-141-3p过表达的评价中国生物医学工程学报(英文版);2009;16。https://doi.org/10.1016/j.ejbt.2022.04.006

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Electronic Journal of Biotechnology 工程技术-生物工程与应用微生物

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Electronic Journal of Biotechnology is an international scientific electronic journal, which publishes papers from all areas related to Biotechnology. It covers from molecular biology and the chemistry of biological processes to aquatic and earth environmental aspects, computational applications, policy and ethical issues directly related to Biotechnology. The journal provides an effective way to publish research and review articles and short communications, video material, animation sequences and 3D are also accepted to support and enhance articles. The articles will be examined by a scientific committee and anonymous evaluators and published every two months in HTML and PDF formats (January 15th , March 15th, May 15th, July 15th, September 15th, November 15th). The following areas are covered in the Journal: • Animal Biotechnology • Biofilms • Bioinformatics • Biomedicine • Biopolicies of International Cooperation • Biosafety • Biotechnology Industry • Biotechnology of Human Disorders • Chemical Engineering • Environmental Biotechnology • Food Biotechnology • Marine Biotechnology • Microbial Biotechnology • Molecular Biology and Genetics •Nanobiotechnology • Omics • Plant Biotechnology • Process Biotechnology • Process Chemistry and Technology • Tissue Engineering