Acute and Remote Thrombotic Complications in Patients with Implanted Drug-eluting Stents; Influence of Smoking as a Risk Factor

Q4 Medicine

Journal of the Hong Kong College of Cardiology Pub Date : 2019-04-01 DOI:10.55503/2790-6744.1008

M. Stojanović, R. Babic, Z. Stajič, M. Čizmić, Violeta Iric Cupic

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Abstract

AL: Acute and Remote Thrombotic Complications in Patients with Implanted Drug-eluting Stents; Influence of Smoking as a Risk Factor. The use of percutaneous coronary intervention (PCI) with the procedural success and continuous technological improvements contributed to a better treatment of coronary heart disease also resulted in the development of acute and remote thrombotic complications. Environmental factors such as smoking significantly worsen unwanted cardiac events after percutaneous coronary intervention. The aim of this study was to determine the influence of risk factors (smoking) the number and severity of adverse cardiac events and its possible selective effect on the formation of acute and subacute thrombotic complications during the application of stents coated with paclitaxel (PES) and sirolimus-coated stents (SES). The study was based on a five-year follow-up of all consecutive patients at the Institute for Cardiovascular Diseases Dedinje in which are embedded drug-eluting stents with sirolimus (Cyphar) and paclitaxel (Taxus). Average age of the tested population was 68.4 ± 8.4 years, of which 585 patients were men (83.4%) and 116 (16.6%) women. Four patients (0.6%) died. Myocardial infarction occurred in nine patients (1.3%). The overall incidence of MACE events was 14.5%, which was registered in 102 patients. Stent thrombosis, definite criteria according to ARC, occurred in 22 patients (3.14%). Probable stent thrombosis was observed in 1 patient (0.14%), possible stent thrombosis in 1 patient (0.14%). Sirolimus and paclitaxel-coated stents are safe and effective means of percutaneous coronary interventions conducted for treatment of atherosclerotic coronary artery disease. Research has shown a large impact of smoking as a risk factor in the development of adverse cardiac events. (J HK Coll Cardiol 2019;27:1-10

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药物洗脱支架植入术患者的急性和远期血栓并发症吸烟作为危险因素的影响

AL：植入药物洗脱支架患者的急性和远处血栓并发症；吸烟作为一个危险因素的影响。经皮冠状动脉介入治疗（PCI）的使用，随着手术的成功和技术的不断改进，有助于更好地治疗冠心病，也导致了急性和远处血栓并发症的发展。吸烟等环境因素会显著加重经皮冠状动脉介入治疗后的不良心脏事件。本研究的目的是确定在应用紫杉醇涂层支架（PES）和西罗莫司涂层支架（SES）期间，风险因素（吸烟）、不良心脏事件的数量和严重程度及其对急性和亚急性血栓性并发症形成的可能选择性影响。该研究基于对Dedinje心血管疾病研究所所有连续患者的五年随访，其中植入了西罗莫司（Cyphar）和紫杉醇（Taxus）药物洗脱支架。受试人群的平均年龄为68.4±8.4岁，其中585名患者为男性（83.4%），116名患者为女性（16.6%）。4名患者（0.6%）死亡。心肌梗死发生在9名患者中（1.3%）。MACE事件的总发生率为14.5%，记录在102名患者中。支架血栓形成是ARC的明确标准，发生在22名患者（3.14%）中。1名患者（0.14%）可能出现支架血栓形成，1名患者可能出现支架栓塞（0.14%。西罗莫司和紫杉醇涂层支架是经皮冠状动脉介入治疗动脉粥样硬化性冠状动脉疾病的安全有效手段。研究表明，吸烟是心脏不良事件发生的一个危险因素，其影响很大。（香港心脏病学杂志2019；27:1-10

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来源期刊

Journal of the Hong Kong College of Cardiology Medicine-Cardiology and Cardiovascular Medicine

CiteScore

0.30

自引率

0.00%

发文量

期刊介绍： The Journal of the Hong Kong College of Cardiology publishes peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, review articles and experimental investigations. As official journal of the Hong Kong College of Cardiology, the journal publishes abstracts of reports to be presented at the Scientific Sessions of the College as well as reports of the College-sponsored conferences.