Effects of the metaplasticity-based theta-burst transcranial stimulation protocols on working memory performance

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL

Bulletin of Russian State Medical University Pub Date : 2023-04-01 DOI:10.24075/brsmu.2023.011

I. Bakulin, A. Zabirova, A. Poydasheva, D. Sinitsyn, D. Lagoda, N. Suponeva, M. Piradov

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引用次数: 1

Abstract

The study of the metaplasticity-based transcranial magnetic stimulation (TMS) protocols is an extensively studied approach to increase the effectiveness of stimulation. However, the effects of protocols with different intervals between the TMS blocks on cognitive functions are poorly understood. The study was aimed to assess the effects of two theta-burst transcranial stimulation (iTBS) protocols with short and long intervals between blocks on the working memory (WM) performance in healthy volunteers. A total of 16 participants were underwent a single TMS session of each protocol, which were applied in random order (iTBS 0–15 — two iTBS blocks over the left dorsolateral prefrontal cortex (DLPFC) iTBS with an interval of 15 min between blocks followed by stimulation of the vertex area in 60 min after the first block; iTBS 0–60 — iTBS block over the left DLPFC iTBS, block of the vertex stimulation after 15 min, and the second block of iTBS over the left DLPFC iTBS 60 min after the first one; iTBS 0 — one block of iTBS over the left DLPFC iTBS and two blocks of the vertex stimulation; control protocol — three blocks of the vertex stimulation with similar intervals). WM was assessed using the n-back test before the first block and after the second and the third stimulation blocks. No significant effects of protocols on WM or differences between protocols in alterations of test results and the responder rates to TMS between protocols were observed. The trend toward statistical signficance was reported for the protocol with short interval (iTBS 0–15). Furthermore, low reproducibility of individual iTBS effect was reported. The study of protocols with short intervals between blocks involving larger cohort of volunteers and taking into account the other factors potentially influencing the effect of the protocol (number of blocks and duration of a single block) seems to be promising.

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基于化塑性的θ突发经颅刺激方案对工作记忆表现的影响

基于化塑性的经颅磁刺激（TMS）方案的研究是一种广泛研究的提高刺激有效性的方法。然而，TMS块之间具有不同间隔的协议对认知功能的影响尚不清楚。该研究旨在评估两个θ突发经颅刺激（iTBS）方案对健康志愿者工作记忆（WM）表现的影响。共有16名参与者接受了每种方案的单一TMS会话，这些会话以随机顺序应用（iTBS 0–15——左背外侧前额叶皮层（DLPFC）iTBS上的两个iTBS块，块之间的间隔为15分钟，然后在第一个块之后的60分钟内刺激顶点区域；iTBS 0–60——左侧DLPFC iTBS上的iTBS块，15分钟后的顶点刺激块，以及第一个iTBS后60分钟左侧DLPFC iTBS上第二个iTBS块；iTBS 0——左DLPFC iTBS上的一个iTBS块和两个顶点刺激块；控制协议——具有相似间隔的顶点刺激的三个块）。在第一个刺激块之前以及在第二个和第三个刺激块之后使用n-back测试来评估WM。没有观察到方案对WM的显著影响，也没有观察到协议之间在测试结果和TMS应答率变化方面的差异。报告了短间隔方案（iTBS 0–15）的统计学显著性趋势。此外，据报道，个别iTBS效应的再现性较低。研究区块间隔较短的方案，涉及更大的志愿者队列，并考虑到可能影响方案效果的其他因素（区块数量和单个区块的持续时间），似乎是有希望的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Russian State Medical University MEDICINE, GENERAL & INTERNAL-

CiteScore

0.80

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0.00%

发文量

期刊介绍： Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.