Palliative surgical treatment using photodynamic therapy for biliary cancer complicated by obstructive jaundice

Q3 Medicine

Biomedical Photonics Pub Date : 2023-08-21 DOI:10.24931/2413-9432-2023-12-2-4-10

A. Tseimakh, A. N. Mitshenko, V. Kurtukov, Ia. N. Shoykhet

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Abstract

The article presents the results of a study of survival, markers of hemostasis, proteolysis, and tumor invasion after complex palliative treatment of patients with histologically verified malignant tumors of the bile ducts complicated by obstructive jaundice in two comparable groups of patients. The aim of the study was to evaluate the effectiveness of palliative surgical treatment using photodynamic therapy in patients with malignant tumors of the biliary system complicated by obstructive jaundice. In 10 patients of the main group, palliative surgical treatment was performed using photodynamic therapy; in 20 patients of the comparison group, palliative surgical treatment was performed without photodynamic therapy. In patients of the main group, a statistically significant increase in life expectancy by 104 days (p=0.033) was observed compared to the comparison group. At the same time, a statistically significant effect of tumor necrosis factor α, a marker of tumor invasion, on survival (p = 0.012) and a decrease in its level after photodynamic therapy by 15 pg/ml (p=0.041) was revealed. Thus, palliative treatment using photodynamic therapy of malignant tumors of the bile ducts, complicated by obstructive jaundice, can increase the survival rate of patients by reducing tumor invasion.

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胆道癌合并梗阻性黄疸的光动力姑息性手术治疗

这篇文章介绍了两组可比较的胆管恶性肿瘤合并梗阻性黄疸患者在接受复杂姑息治疗后的生存率、止血指标、蛋白溶解和肿瘤侵袭的研究结果。本研究的目的是评价采用光动力疗法对胆道系统恶性肿瘤合并梗阻性黄疸患者姑息性手术治疗的有效性。主组10例采用光动力疗法行姑息性手术治疗;对照组20例患者行姑息性手术治疗，不进行光动力治疗。主组患者预期寿命较对照组延长104天，差异有统计学意义(p=0.033)。同时，肿瘤侵袭标志物肿瘤坏死因子α对生存率的影响有统计学意义(p= 0.012)，光动力治疗后肿瘤坏死因子α水平降低15 pg/ml (p=0.041)。因此，对合并梗阻性黄疸的胆管恶性肿瘤采用光动力姑息治疗，可减少肿瘤侵袭，提高患者生存率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Photonics Medicine-Surgery

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The main goal of the journal – to promote the development of Russian biomedical photonics and implementation of its advances into medical practice. The primary objectives: - Presentation of up-to-date results of scientific and in research and scientific and practical (clinical and experimental) activity in the field of biomedical photonics. - Development of united Russian media for integration of knowledge and experience of scientists and practitioners in this field. - Distribution of best practices in laser medicine to regions. - Keeping the clinicians informed about new methods and devices for laser medicine - Approval of investigations of Ph.D candidates and applicants.