Hand-held optical coherence tomography: advancements in detection and assessment of optic nerve abnormalities and disease progression monitoring

IF 0.9 Q4 OPHTHALMOLOGY

Expert Review of Ophthalmology Pub Date : 2022-03-04 DOI:10.1080/17469899.2022.2060821

E. Papageorgiou, Katerina Lazari, I. Gottlob

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引用次数: 1

Abstract

ABSTRACT Introduction Developmental abnormalities of the optic nerve (ON) and pediatric optic neuropathies, such as glaucoma, are leading causes of childhood blindness. The recent development of hand-held spectral domain optical coherence tomography (HH-OCT) has enabled noncontact, high-resolution scanning in non-sedated newborns, infants, and young children and has provided for the first time, in vivo visualization of the retina and ON in these patient groups. Areas covered This review will address the applications, recent advances, and future potential of HH-OCT in diagnosis and monitoring of pediatric optic neuropathies. We will provide an update on the use of HH-OCT in pediatric glaucoma, congenital optic disc anomalies, optic pathway gliomas, optic atrophy, and papilledema. Expert opinion HH-OCT could offer particular utility in children with optic neuropathies, by providing noninvasive, high-resolution characterization of the optic nerve head. Optic nerve parameters, such as retinal nerve fiber layer thickness, could serve as biomarkers to assess the severity of optic nerve disease qualitatively and quantitatively. Hence, HH-OCT is emerging as a powerful imaging tool to facilitate early diagnosis, identify prognostic biomarkers, monitor disease progression, and assess response to treatment.

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手持光学相干断层扫描:视神经异常和疾病进展监测的检测和评估进展

摘要简介视神经发育异常和儿童视神经病变，如青光眼，是儿童失明的主要原因。手持式光谱域光学相干断层扫描（HH-OCT）的最新发展使未服用镇静剂的新生儿、婴儿和幼儿能够进行非接触式高分辨率扫描，并首次为这些患者组的视网膜和ON提供了体内可视化。本综述将介绍HH-OCT在儿童视神经病变诊断和监测中的应用、最新进展和未来潜力。我们将提供HH-OCT在儿童青光眼、先天性视盘异常、视神经胶质瘤、视神经萎缩和视乳头水肿中的最新应用。专家意见HH-OCT可以通过提供视神经头的非侵入性、高分辨率特征，在儿童视神经病变中提供特别的实用性。视神经参数，如视网膜神经纤维层厚度，可以作为定性和定量评估视神经疾病严重程度的生物标志物。因此，HH-OCT正在成为一种强大的成像工具，有助于早期诊断、确定预后生物标志物、监测疾病进展和评估治疗反应。

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来源期刊

Expert Review of Ophthalmology Health Professions-Optometry

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The worldwide problem of visual impairment is set to increase, as we are seeing increased longevity in developed countries. This will produce a crisis in vision care unless concerted action is taken. The substantial value that ophthalmic interventions confer to patients with eye diseases has led to intense research efforts in this area in recent years, with corresponding improvements in treatment, ophthalmic instrumentation and surgical techniques. As a result, the future for ophthalmology holds great promise as further exciting and innovative developments unfold.