Repellent rings at titanium cylinders against overgrowth by fibroblasts

IF 2.3 Q2 OPTICS

Advanced Optical Technologies Pub Date : 2020-05-01 DOI:10.1515/aot-2019-0070

Peter Fosodeder, W. Baumgartner, C. Steinwender, A. W. Hassel, C. Florian, J. Bonse, J. Heitz

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引用次数: 6

Abstract

Abstract The invention of new miniaturized and smart medical implants continues in all medical fields, including miniaturized heart pacemakers. These implants often come with a titanium (Ti) casing, which may have to be removed after several months or years and shall therefore not be completely overgrown by cells or scar tissue after implantation. Scar tissue is mainly formed by fibroblast cells and extracellular matrix proteins like collagen produced by them. Suppression of fibroblast growth at Ti surfaces could be achieved by 800 nm femtosecond laser-ablation creating self-organized sharp spikes with dimensions in the 10 μm-range which are superposed by fine sub-μm parallel ripples. On flat Ti control samples, the best results regarding suppression of cell growth were obtained on spike-structures which were additionally electrochemically anodized under acidic conditions. When Ti cylinders with a diameter of 8 mm (similar as the pacemakers) were placed upright in a culture of murine fibroblasts, a multi-layer cell growth up to a height of at least 1.5 mm occurred within 19–22 days. We have demonstrated that a laser-structured and anodized ring around the Ti cylinder surface is an effective way to create a barrier that murine fibroblasts were not able to overgrow within this time.

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钛圆柱体上的排斥环防止成纤维细胞过度生长

摘要新型微型和智能医疗植入物的发明在所有医疗领域都在继续，包括微型心脏起搏器。这些植入物通常带有钛（Ti）外壳，可能需要在几个月或几年后取出，因此植入后不会被细胞或疤痕组织完全过度生长。瘢痕组织主要由成纤维细胞及其产生的胶原等细胞外基质蛋白形成。通过800nm飞秒激光消融可以抑制Ti表面的成纤维细胞生长，产生尺寸在10μm范围内的自组织尖锐尖峰，这些尖峰由精细的亚μm平行波纹叠加。在平坦的Ti对照样品上，在酸性条件下额外电化学阳极氧化的尖峰结构上获得了关于抑制细胞生长的最佳结果。当直径为8 mm的Ti圆柱体（类似于起搏器）直立放置在小鼠成纤维细胞培养物中时，19-22天内发生了高达至少1.5 mm的多层细胞生长。我们已经证明，在Ti圆柱体表面周围的激光结构和阳极氧化环是一种有效的方法，可以创建一个屏障，使小鼠成纤维细胞在这段时间内无法过度生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Optical Technologies OPTICS-

CiteScore

4.40

自引率

0.00%

发文量

期刊介绍： Advanced Optical Technologies is a strictly peer-reviewed scientific journal. The major aim of Advanced Optical Technologies is to publish recent progress in the fields of optical design, optical engineering, and optical manufacturing. Advanced Optical Technologies has a main focus on applied research and addresses scientists as well as experts in industrial research and development. Advanced Optical Technologies partners with the European Optical Society (EOS). All its 4.500+ members have free online access to the journal through their EOS member account. Topics: Optical design, Lithography, Opto-mechanical engineering, Illumination and lighting technology, Precision fabrication, Image sensor devices, Optical materials (polymer based, inorganic, crystalline/amorphous), Optical instruments in life science (biology, medicine, laboratories), Optical metrology, Optics in aerospace/defense, Simulation, interdisciplinary, Optics for astronomy, Standards, Consumer optics, Optical coatings.