The Microbiome and Aging.

IF 8.7 1区生物学 Q1 GENETICS & HEREDITY

Annual review of genetics Pub Date : 2019-12-03 DOI:10.1146/annurev-genet-112618-043650

Bianca Bana, F. Cabreiro

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引用次数: 110

Abstract

Aging is a natural process of organismal decay that underpins the development of myriad diseases and disorders. Extensive efforts have been made to understand the biology of aging and its regulation, but most studies focus solely on the host organism. Considering the pivotal role of the microbiota in host health and metabolism, we propose viewing the host and its microbiota as a single biological entity whose aging phenotype is influenced by the complex interplay between host and bacterial genetics. In this review we present how the microbiota changes as the host ages, but also how the intricate relationship between host and indigenous bacteria impacts organismal aging and life span. In addition, we highlight other microbiota-dependent mechanisms that potentially regulate aging, and present experimental animal models for addressing these questions. Importantly, we propose microbiome dysbiosis as an additional hallmark and biomarker of aging. Expected final online publication date for the Annual Review of Genetics, Volume 53 is November 23, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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微生物组与衰老。

衰老是一个有机物腐烂的自然过程，是无数疾病和病症发展的基础。人们已经做出了广泛的努力来理解衰老的生物学及其调控，但大多数研究只关注宿主生物。考虑到微生物群在宿主健康和代谢中的关键作用，我们建议将宿主及其微生物群视为一个单一的生物实体，其衰老表型受到宿主和细菌遗传学之间复杂相互作用的影响。在这篇综述中，我们介绍了微生物群如何随着宿主年龄的增长而变化，以及宿主和本土细菌之间的复杂关系如何影响生物体的衰老和寿命。此外，我们强调了其他可能调节衰老的微生物群依赖性机制，并提出了解决这些问题的实验动物模型。重要的是，我们提出微生物组失调是衰老的一个额外标志和生物标志。《遗传学年度评论》第53卷预计最终在线出版日期为2019年11月23日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of genetics 生物-遗传学

CiteScore

18.30

自引率

0.90%

发文量

期刊介绍： The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.