To Evaluate the Efficacy of Biomarkers as Monitoring Tool in Patients with Fascial Space Infections of Odontogenic Origin: A Clinical Study.

IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Maxillofacial & Oral Surgery Pub Date : 2024-02-01 Epub Date: 2022-05-07 DOI:10.1007/s12663-022-01722-5

Mehak Malhotra, Tejinder Kaur, Sahiba Kukreja, Ramandeep Singh Bhullar, Amit Dhawan, Amneet Sandhu

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引用次数: 0

Abstract

Introduction: The objective was to evaluate the efficacy of biochemical markers (WBC, CRP and fibrinogen) and the course of odontogenic space infections in 50 patients.

Material and methods: Blood samples were taken preoperatively and postoperatively at day 0, day 4, day 8 and day 12 for measuring the levels of all three biomarkers. The trends of the biomarkers were observed and compared with assessment parameters such as dental etiology, number of teeth involved, number of spaces involved, mouth opening and pain. Active pus discharge, dysphagia, hoarseness and swelling were assessed and scored accordingly.

Results: The data were subjected to paired 't' test, McNemar's and Pearson's bivariate correlation as appropriate. Statistical analysis found strong correlation between laboratory values of markers and parameters used to measure severity of infection. All three biomarkers (WBC, CRP and fibrinogen) are significant markers for hospital stay (p < 0.01). Prospective analysis indicates that only one biomarker cannot be used to rule out specific diagnosis.

Conclusion: The combination of three biochemical markers assessed in the present study (WBC, CRP and fibrinogen) should be used as prognostic factor in assessment, clinical severity and efficacy of treatment regime for patients as these can reliably predict the clinical course of odontogenic infection.

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评价生物标志物作为牙源性筋膜间隙感染患者监测工具的疗效:一项临床研究

引言目的是评估生化指标（白细胞、CRP和纤维蛋白原）的疗效以及50名患者牙源性间隙感染的过程：术前和术后分别在第 0 天、第 4 天、第 8 天和第 12 天采集血样，测量所有三种生物标志物的水平。观察生物标志物的变化趋势，并将其与牙科病因、受累牙齿数量、受累牙间隙数量、张口度和疼痛等评估参数进行比较。对活动性脓性分泌物、吞咽困难、声音嘶哑和肿胀进行评估和相应评分：对数据酌情进行配对 "t "检验、McNemar's 检验和 Pearson's 双变量相关检验。统计分析发现，实验室指标值与用于衡量感染严重程度的参数之间存在很强的相关性。所有三种生物标志物（白细胞、CRP 和纤维蛋白原）都是住院时间的重要标志物（P < 0.01）。前瞻性分析表明，仅用一种生物标志物不能排除特定的诊断：本研究中评估的三种生化标志物（白细胞、CRP 和纤维蛋白原）的组合应作为预后因素，用于评估患者的临床严重程度和治疗方案的疗效，因为这些标志物可以可靠地预测牙源性感染的临床过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Maxillofacial & Oral Surgery DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

1.90

自引率

0.00%

发文量

138

期刊介绍： This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.