GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells.

IF 3.1 3区 工程技术 Q2 NEUROSCIENCES
Cognitive Neurodynamics Pub Date : 2024-06-01 Epub Date: 2023-04-08 DOI:10.1007/s11571-023-09950-2
Min Dai, Pei-Ji Liang
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引用次数: 0

Abstract

Two coordinated dynamic properties (adaptation and sensitization) are observed in retinal ganglion cells (RGCs) under the contrast stimulation. During sustained high-contrast period, adaptation decreases RGCs' responses while sensitization increases RGCs' responses. In mouse retina, adaptation and sensitization respectively show OFF- and ON-pathway-dominance. However, the mechanisms which drive the differentiation between adaptation and sensitization remain unclear. In the present study, multi-electrode recordings were conducted on isolated mouse retina under full-field contrast stimulation. Dynamic property was quantified based on the trend of RGC's firing rate during high-contrast period, light sensitivity was estimated by linear-nonlinear analysis and coding ability was estimated through stimulus reconstruction algorism. γ-Aminobutyric acid (GABA) receptors were pharmacologically blocked to explore the relation between RGCs' dynamic property and the activity of GABA receptors. It was found that GABAA and GABAC receptors respectively mediated the adaptation and sensitization processes in RGCs' responses. RGCs' dynamic property changes occurred after the blockage of GABA receptors were related to the modulation of the cells' light sensitivity. Further, the blockage of GABAA (GABAC) receptor significantly decreased RGCs' overall coding ability and eliminated the functional benefits of adaptation (sensitization). Our work suggests that the dynamic property of individual RGC is related to the balance between its GABAA-receptor-mediated inputs and GABAC-receptor-mediated inputs. Blockage of GABA receptors breaks the balance of retinal circuitry for signal processing, and down-regulates the visual information coding ability.

Supplementary information: The online version contains supplementary material available at 10.1007/s11571-023-09950-2.

GABA受体介导小鼠视网膜神经节细胞的适应和致敏过程
在对比度刺激下,在视网膜神经节细胞(RGCs)中观察到两种协调的动态特性(适应和敏化)。在持续的高对比度时期,适应会降低视网膜神经节细胞的反应,而敏化则会增加视网膜神经节细胞的反应。在小鼠视网膜中,适应和敏化分别表现为关闭和开启通路主导。然而,驱动适应和敏化分化的机制仍不清楚。本研究在全场对比刺激下对离体小鼠视网膜进行了多电极记录。根据高对比度时期 RGC 的发射率趋势量化动态特性,通过线性-非线性分析估计光敏感性,并通过刺激重建算法估计编码能力。通过药理阻断γ-氨基丁酸(GABA)受体来探讨RGCs的动态特性与GABA受体活性之间的关系。结果发现,GABAA和GABAC受体分别介导了RGCs反应的适应和敏化过程。阻断GABA受体后,RGCs的动态特性发生了变化,这与细胞对光的敏感性的调节有关。此外,阻断GABAA(GABAC)受体会显著降低RGCs的整体编码能力,并消除适应(敏化)的功能益处。我们的研究表明,单个 RGC 的动态特性与其 GABAA 受体介导的输入和 GABAC 受体介导的输入之间的平衡有关。阻断 GABA 受体会打破视网膜信号处理电路的平衡,并下调视觉信息编码能力:在线版本包含补充材料,可查阅 10.1007/s11571-023-09950-2。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cognitive Neurodynamics
Cognitive Neurodynamics 医学-神经科学
CiteScore
6.90
自引率
18.90%
发文量
140
审稿时长
12 months
期刊介绍: Cognitive Neurodynamics provides a unique forum of communication and cooperation for scientists and engineers working in the field of cognitive neurodynamics, intelligent science and applications, bridging the gap between theory and application, without any preference for pure theoretical, experimental or computational models. The emphasis is to publish original models of cognitive neurodynamics, novel computational theories and experimental results. In particular, intelligent science inspired by cognitive neuroscience and neurodynamics is also very welcome. The scope of Cognitive Neurodynamics covers cognitive neuroscience, neural computation based on dynamics, computer science, intelligent science as well as their interdisciplinary applications in the natural and engineering sciences. Papers that are appropriate for non-specialist readers are encouraged. 1. There is no page limit for manuscripts submitted to Cognitive Neurodynamics. Research papers should clearly represent an important advance of especially broad interest to researchers and technologists in neuroscience, biophysics, BCI, neural computer and intelligent robotics. 2. Cognitive Neurodynamics also welcomes brief communications: short papers reporting results that are of genuinely broad interest but that for one reason and another do not make a sufficiently complete story to justify a full article publication. Brief Communications should consist of approximately four manuscript pages. 3. Cognitive Neurodynamics publishes review articles in which a specific field is reviewed through an exhaustive literature survey. There are no restrictions on the number of pages. Review articles are usually invited, but submitted reviews will also be considered.
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