Lactate: an intracellular metabolite regulates cell cycle progression

Abstract

The Chouchani lab recently reported in Nature that a dynamic intracellular lactate is a physiological regulator for cell cycle progress. They also showed that accumulated lactate in cell mitosis directly binds and inhibits Sentrin/SUMO-specific protease 1 (SENP1) to enrich SUMO2/3-modification of anaphase-promoting complex 4 (APC4), which promotes the degradation of APC/C complexes, leading to mitosis exit.