Electrochemical DNA Biosensors Based on the Intrinsic Topological Insulator BiSbTeSe2 for Potential Application in HIV Determination

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2022-02-14 DOI:10.1021/acsabm.1c01153

Yujiu Jiang, Shanshan Li, Peng Zhu, Jinge Zhao, Xiaolu Xiong, Yetong Wu, Xu Zhang, Yongkai Li, Tinglu Song, Wende Xiao, Zhiwei Wang*, Junfeng Han*

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引用次数: 3

Abstract

In this work, we reported a sensitive, label-free electrochemical biosensor based on the intrinsic topological insulator (TI) BiSbTeSe₂ for potential application in the determination of the HIV gene. With strong spin–obit coupling, TIs could have robust surface states with low electronic noise, which might be beneficial for the stable and sensitive electron transport between the electrode and electrolyte interface. Under optimized conditions of the biosensors using BiSbTeSe₂, the differential pulse voltammetry (DPV) peak currents showed a linear relationship with the logarithm of target DNA concentrations ranging from 1.0 × 10^–13 to 1.0 × 10^–7 M, with a detection limit of 1.07 × 10^–15 M. The sensing assay also displayed good selectivity and stability after storage at 4 °C for 7 days. This work provides an effective way to develop biosensors with topological materials, which have a potential application in the clinical determination and monitoring field.

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基于内禀拓扑绝缘体BiSbTeSe2的电化学DNA生物传感器在HIV检测中的潜在应用

在这项工作中，我们报道了一种敏感的、无标记的电化学生物传感器，该传感器基于固有拓扑绝缘体(TI) BiSbTeSe2，有望应用于HIV基因的检测。由于具有较强的自旋轨道耦合，ti具有鲁棒的表面态和较低的电子噪声，这可能有利于在电极和电解质界面之间稳定而敏感的电子传递。在优化的BiSbTeSe2生物传感器条件下，差分脉冲伏安(DPV)峰值电流与目标DNA浓度的对数呈线性关系，范围为1.0 × 10-13 ~ 1.0 × 10-7 M，检测限为1.07 × 10-15 M，检测方法在4°C保存7 d后具有良好的选择性和稳定性。本研究为利用拓扑材料制备生物传感器提供了一条有效途径，在临床检测和监测领域具有潜在的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.