Distribution and similarity of allergens in children in the same family

中国综合临床 Pub Date : 2019-11-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2019.06.011

Xiaoqian Chen, Huiqing Ye, Zhuang-gui Chen, H. Zhong, Chan-qing Luo, Liyi He, Mingwei Liu

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引用次数: 0

Abstract

Objective To investigate and analyze the similarities of allergens in children of the same family with susceptibility to the same genetic background and environmental factors. Methods From January 2013 to December 2017, a total of 142 pairs of children with allergic diseases aged 0-15 years and their siblings (284 cases) were collected from the outpatient or hospitalized treatment of Pediatrics and otolaryngology department of the First People′s Hospital of Foshan City, the Third Affiliated Hospital of Sun Yat-sen University.The elder group was brother or sister (142 cases), and the younger group was brother or sister (142 cases). The serum allergen sIgE was tested by Allergy Screen allergen detection system (developed by Germany MEDIWISS Company) and the similarity of allergens was analyzed. Results A total of 142 siblings (284 cases) had systemic symptoms of allergic diseases in varying degrees, including respiratory symptoms (cough (47 cases in the old group, 32 cases in the young group), χ2=3.946, P=0.047), nasal obstruction (41 cases in the old group, 19 cases in the young group, χ2=10.227, P=0.001), runny nose (46 cases in the old group, 26 cases in the young group, χ2=7.442, P=0.006), gastrointestinal symptoms (abdominal pain (11cases in the old group, 7 cases in the young group, χ2=4.63, P=0.031), skin symptoms(urticaria (18 cases in the old group, 8 cases in the young group, χ2=4.234, P=0.037)) and so on, the difference was statistically significant.Some children have multiple organ system symptoms at the same time.There was no significant difference between the old group and the young group in the early use of antibiotics, mode of production and feeding mode within 6 months (all P>0.05). Among the two groups, house dust mite and cockroach (r=0.831, P<0.05), dog hair and house dust (r=0.717, P<0.05), cypress, elm, willow, birch, oak, maple, walnut, sycamore, poplar and Dianqing, branching, yanqu, and heiqu (r=0.683, P<0.05). Conclusion With the same genetic background and the same environmental factors, the allergens in siblings are similar. Key words: Siblings; Allergen; Similarity

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同一家庭儿童过敏原的分布及相似性

目的调查和分析对相同遗传背景和环境因素易感的同一家庭儿童过敏原的相似性。方法自2013年1月至2017年12月，收集佛山市第一人民医院儿耳鼻喉科门诊或住院治疗的142对0-15岁过敏性疾病患儿及其兄弟姐妹284例，中山大学附属第三医院。老年组为兄弟姐妹（142例），年轻组为兄弟姊妹（142例。采用德国MEDIWIS公司开发的Allergy Screen过敏原检测系统检测血清过敏原sIgE，并分析过敏原的相似性。结果共有142例（284例）兄弟姐妹有不同程度的过敏性疾病全身症状，包括呼吸道症状（咳嗽（老年组47例，青年组32例），χ2=3.946，P=0.047），鼻腔阻塞（老年组41例，年轻组19例，χ2=10.227，P=0.001），流鼻涕（老年组46例，青年组26例，χ2=7.442，P=0.006）、胃肠道症状（腹部疼痛（老年组11例，年轻组7例，χ2=4.63，P=0.031）、皮肤症状（荨麻疹（老年组18例，年青组8例，χ2*4.234，P=0.037）等，差异有统计学意义。有些儿童同时有多种器官系统症状。老年组和青年组在6个月内抗生素的早期使用、生产方式和饲养方式上无显著差异（均P>0.05），结论在相同的遗传背景和相同的环境因素下，兄弟姐妹的过敏原相似。关键词：兄弟姐妹；过敏原；相似性

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.