Danielle I. Kay MD, Lauren M. Theiss MD, Daniel I. Chu MD MSPH
{"title":"Epidemiology and pathophysiology of low anterior resection syndrome","authors":"Danielle I. Kay MD, Lauren M. Theiss MD, Daniel I. Chu MD MSPH","doi":"10.1016/j.scrs.2021.100844","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span><span><span>Low anterior resection syndrome (LARS) is a constellation of symptoms that includes incontinence to </span>flatus<span> and/or feces, urgency, and frequency. LARS affects up to 80% of patients after low anterior resection. The pathophysiology<span> of LARS is complex, and a variety of mechanisms have been proposed. These mechanisms include disruption of autonomic innervation and the rectoanal inhibitory reflex, </span></span></span>internal anal sphincter dysfunction, decreased </span>anal canal sensation, and decreased capacity and compliance of the neorectum. As the management of colorectal diseases such as </span>rectal cancer continues to improve, there is a concomitant increase in organ preservation, </span>survivorship<span>, and attention to quality of life<span>. Therefore, recognition and understanding of LARS is key to the diagnosis and treatment of this debilitating disease process.</span></span></p></div>","PeriodicalId":55956,"journal":{"name":"Seminars in Colon and Rectal Surgery","volume":"32 4","pages":"Article 100844"},"PeriodicalIF":0.4000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Colon and Rectal Surgery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1043148921000439","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 1
Abstract
Low anterior resection syndrome (LARS) is a constellation of symptoms that includes incontinence to flatus and/or feces, urgency, and frequency. LARS affects up to 80% of patients after low anterior resection. The pathophysiology of LARS is complex, and a variety of mechanisms have been proposed. These mechanisms include disruption of autonomic innervation and the rectoanal inhibitory reflex, internal anal sphincter dysfunction, decreased anal canal sensation, and decreased capacity and compliance of the neorectum. As the management of colorectal diseases such as rectal cancer continues to improve, there is a concomitant increase in organ preservation, survivorship, and attention to quality of life. Therefore, recognition and understanding of LARS is key to the diagnosis and treatment of this debilitating disease process.
期刊介绍：
Seminars in Colon and Rectal Surgery offers a comprehensive and coordinated review of a single, timely topic related to the diagnosis and treatment of proctologic diseases. Each issue is an organized compendium of practical information that serves as a lasting reference for colorectal surgeons, general surgeons, surgeons in training and their colleagues in medicine with an interest in colorectal disorders.
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