Recent Trends in Treatment of Multidrug Resistant-Tuberculosis-A Review

Abstract

Drug resistance is reduction in effectiveness of an anti-microbial agents used in inhibiting the microorganisms or curing a disease. Mycobacterium tuberculosis is responsible for causing tuberculosis can acquire multiple drug resistance by not responding to Isoniazid and Rifampicin the two most powerful anti-TB agents. The complications of drug resistance in TB elevates due to some of the risk factors like inadequate treatment compliance, noncompliance of the patients to the treatment. Proper diagnosis of the disease and switching to modified drug therapy may improve the treatment outcome. The drug treatment involves usage of combination of drugs Isoniazid, Rifampicin, Ethambutol along with other antimicrobial agents, and nutritional therapy, immunotherapy. In this review we discussed about the occurrence, treatment of multi drug resistance tuberculosis along with drugs under trials and nutritional requirements.