{"title":"Nonvesicular trafficking of cholesterol by aster proteins","authors":"Dougall M. Norris, Y. Aw, Hongyuan Yang","doi":"10.1093/lifemeta/load003","DOIUrl":null,"url":null,"abstract":"\n In a recent article published in Nature Metabolism, Peter Tontonoz and colleagues found that the Aster/GramD1 proteins were required for plasma membrane cholesterol to reach the endoplasmic reticulum in mouse liver during fasting, LDL uptake, or reverse cholesterol transport. The Aster/GramD1 pathway plays a key role in maintaining hepatic and systemic cholesterol/lipid homeostasis.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/lifemeta/load003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In a recent article published in Nature Metabolism, Peter Tontonoz and colleagues found that the Aster/GramD1 proteins were required for plasma membrane cholesterol to reach the endoplasmic reticulum in mouse liver during fasting, LDL uptake, or reverse cholesterol transport. The Aster/GramD1 pathway plays a key role in maintaining hepatic and systemic cholesterol/lipid homeostasis.