Prognostic relevance of optical coherence tomography angiography biomarkers in diabetic macular edema

IF 0.9 Q4 OPHTHALMOLOGY
M. Parravano, S. Fragiotta, G. Querques
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引用次数: 0

Abstract

Optical coherence tomography angiography (OCTA) enables visualization of the retinal capillary plexus structure at various depths, identifying flow density and microaneurysms from the deep capillary plexus (DCP) in diabetic retinopathy (DR) beyond the ability of fluorescein angiography (FA) [1,2]. Diabetic macular edema (DME) is one of the leading causes of vision loss in diabetic patients with a variable and temporary improvement in response to treatment [3]. In this scenario, recognizing particular OCTA features is crucial for identifying the prediction of DME that can be of paramount importance to establishing a better glycometabolic control and thus preventing DME development. Indeed, DME eyes with macular center involvement retaining a good visual acuity of 20/25 letters or better showed no significant differences in vision loss at 2 years in patients managed with aflibercept, laser photocoagulation, or observation [4]. In addition, another important role of OCTA consists in predicting the responsiveness to treatment [5].
光学相干断层扫描血管造影生物标志物与糖尿病黄斑水肿预后的相关性
光学相干断层扫描血管造影(OCTA)能够显示不同深度的视网膜毛细血管丛结构,在糖尿病视网膜病变(DR)中识别血流密度和来自深毛细血管丛(DCP)的微动脉瘤,这是荧光素血管造影(FA)所无法比拟的[1,2]。糖尿病性黄斑水肿(DME)是糖尿病患者视力丧失的主要原因之一,对治疗[3]的反应有可变和暂时的改善。在这种情况下,识别特定的OCTA特征对于确定二甲醚的预测至关重要,这对于建立更好的糖代谢控制从而预防二甲醚的发展至关重要。事实上,黄斑中心受损伤的DME眼保持20/25字母或更好的良好视力,在使用阿非利赛普、激光光凝或观察bbb的患者中,2年后的视力丧失没有显著差异。此外,OCTA的另一个重要作用在于预测对治疗的反应性。
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来源期刊
Expert Review of Ophthalmology
Expert Review of Ophthalmology Health Professions-Optometry
CiteScore
1.40
自引率
0.00%
发文量
39
期刊介绍: The worldwide problem of visual impairment is set to increase, as we are seeing increased longevity in developed countries. This will produce a crisis in vision care unless concerted action is taken. The substantial value that ophthalmic interventions confer to patients with eye diseases has led to intense research efforts in this area in recent years, with corresponding improvements in treatment, ophthalmic instrumentation and surgical techniques. As a result, the future for ophthalmology holds great promise as further exciting and innovative developments unfold.
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