GFAP Alternative Splicing and the Relevance for Disease – A Focus on Diffuse Gliomas

IF 3.9 4区 医学 Q2 NEUROSCIENCES
Jessy V. van Asperen, P. Robe, Elly M. Hol
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引用次数: 7

Abstract

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocytes and neural stem cells, and their malignant analogues in glioma. Since the discovery of the protein 50 years ago, multiple alternative splice variants of the GFAP gene have been discovered, leading to different GFAP isoforms. In this review, we will describe GFAP isoform expression from gene to protein to network, taking the canonical isoforms GFAPα and the main alternative variant GFAPδ as the starting point. We will discuss the relevance of studying GFAP and its isoforms in disease, with a specific focus on diffuse gliomas.
GFAP选择性剪接及其与疾病的相关性——聚焦弥漫性胶质瘤
胶质原纤维酸性蛋白(GFAP)是星形胶质细胞和神经干细胞及其恶性类似物在胶质瘤中的特征性中间丝蛋白。自50年前发现该蛋白以来,已经发现了GFAP基因的多种替代剪接变体,导致不同的GFAP亚型。在这篇综述中,我们将以典型的亚型GFAPα和主要的替代变体GFAPδ为起点,描述从基因到蛋白质再到网络的GFAP亚型表达。我们将讨论研究GFAP及其亚型在疾病中的相关性,特别关注弥漫性胶质瘤。
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来源期刊
ASN NEURO
ASN NEURO NEUROSCIENCES-
CiteScore
7.70
自引率
4.30%
发文量
35
审稿时长
>12 weeks
期刊介绍: ASN NEURO is an open access, peer-reviewed journal uniquely positioned to provide investigators with the most recent advances across the breadth of the cellular and molecular neurosciences. The official journal of the American Society for Neurochemistry, ASN NEURO is dedicated to the promotion, support, and facilitation of communication among cellular and molecular neuroscientists of all specializations.
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