Glucocorticoid ultradian rhythms

Abstract

Ultradian glucocorticoid rhythms are highly conserved across mammalian species and robustly oscillate within a cyclical dynamic signalling network. Despite this, the role of ultradian signalling and the effects of its dysregulation for cognitive processing and metabolic homeostasis is often overlooked within chrono-biological research. This review will discuss ultradian specific signalling and transcriptional mechanisms and the proposed models and repercussion of ultradian dysregulation for cognitive and metabolic function. Highlighting emerging therapeutic treatment that may have significant impacts for future patient care and treatment.