Prenatal exposure to multiple organochlorine compounds and childhood body mass index.

IF 3.3 Q2 ENVIRONMENTAL SCIENCES

Environmental Epidemiology Pub Date : 2022-04-22 eCollection Date: 2022-06-01 DOI:10.1097/EE9.0000000000000201

Elena Colicino, Katerina Margetaki, Damaskini Valvi, Nicolo Foppa Pedretti, Nikos Stratakis, Marina Vafeiadi, Theano Roumeliotaki, Soterios A Kyrtopoulos, Hannu Kiviranta, Euripides G Stephanou, Manolis Kogevinas, Rob McConnell, Kiros T Berhane, Leda Chatzi, David V Conti

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引用次数: 0

Abstract

Background: Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches.

Aim: To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4-12 years of age in 279 Rhea child-mother dyads.

Methods: We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kernel machine regressions (BVCKMR) to model nonlinear and nonadditive associations.

Results: In the LMR, yearly change of BMI measures was consistently associated with a quartile increase in hexachlorobenzene (HCB) (estimate [95% Confidence or Credible interval] BMI: 0.10 [0.06, 0.14]; BMI z-score: 0.02 [0.01, 0.04]). BWQSR results showed that a quartile increase in mixture concentrations was associated with yearly increase of BMI measures (BMI: 0.10 [0.01, 0.18]; BMI z-score: 0.03 [0.003, 0.06]). In the BVCKMR, a quartile increase in dichlorodiphenyldichloroethylene concentrations was associated with higher BMI measures at 4 years (BMI: 0.33 [0.24, 0.43]; BMI z-score: 0.19 [0.15, 0.24]); whereas a quartile increase in HCB and polychlorinated biphenyls (PCB)-118 levels was positively associated with BMI measures yearly change (BMI: HCB:0.10 [0.07, 0.13], PCB-118:0.08 [0.04, 012]; BMI z-score: HCB:0.03 [0.02, 0.05], PCB-118:0.02 [0.002,04]). BVCKMR suggested that PCBs had nonlinear relationships with BMI measures, and HCB interacted with other compounds.

Conclusions: All analyses consistently demonstrated detrimental associations between prenatal OC exposures and childhood BMI measures.

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产前接触多种有机氯化合物与儿童体重指数

背景：产前接触有机氯化合物（OCs）与儿童体重指数（BMI）增加有关；然而，只有少数研究关注纵向BMI轨迹，没有一项研究使用多重接触混合方法。目的：在279对瑞亚母子中，确定子宫内接触8种强迫症与4岁时儿童BMI测量值（BMI和BMI z评分）及其4-12岁时的年变化之间的关系。方法：我们应用了三种方法：（1）线性混合效应回归（LMR）将单个化合物与BMI测量相关联；（2）贝叶斯加权分位数和回归（BWQSR），以提供与BMI测量的总体OC混合关联；以及（3）贝叶斯变系数核机器回归（BVCKMR）来对非线性和非加性关联进行建模。结果：在LMR中，BMI指标的年度变化始终与六氯苯（HCB）的四分位数增加有关（估计[95%置信区间或可信区间]BMI:0.10[0.060.14]；BMIz-评分：0.02[0.010.04]）。BWQSR结果显示，混合物浓度的四分位增加与BMI指标的年度增加有关（BMI:0.10[0.010.18]；BMIZ-评分：0.03[0.0030.06]）。在BVCKMR中，二氯二苯基二氯乙烯浓度的四分位数增加与4岁时较高的BMI测量值相关（BMI:0.33[0.24,0.43]；BMI z评分：0.19[0.15,024]）；而HCB和多氯联苯-118水平的四分位数增加与BMI测量的年变化呈正相关（BMI:HCB:0.10[0.07，0.13]，PCB-118:0.08[0.04，012]；BMI z评分：HCB:0.03[0.02，0.05]，PCB-18:0.02[0.002，04]）。BVCKMR表明，多氯联苯与BMI测量呈非线性关系，并且HCB与其他化合物相互作用。结论：所有分析一致表明，产前OC暴露与儿童BMI测量之间存在有害关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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