Advantages of nasogastric tube feeding during neoadjuvant concurrent chemoradiotherapy for esophageal cancer: A retrospective study

Q1 Health Professions
Jie Dong , Qingwu Du , Tian Zhang , Xi Chen , Wencheng Zhang , Yajun Chen , Yaqi Zeng , Chunlei Li , Yueying Li , Yujie Wang , Kun Wang , Qingsong Pang
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引用次数: 0

Abstract

Objective

To compare the effects of oral intake and nasogastric tube (NG) feeding on nutritional status, complications and survival during neoadjuvant chemoradiotherapy for esophageal squamous-cell carcinoma (ESCC) patients.

Methods

A total of 61 ​ESCC cases treated with neoadjuvant chemoradiotherapy from December 2018 to March 2020 were enrolled, including (38 in oral intake group, and 22 in NG feeding group. Disease characteristics and baseline nutritional markers were collected in both groups. Nutritional status, complication and completion rate of chemoradiotherapy in both groups were evaluated.

Results

Compared with the oral intake group, patients in the NG feeding group had a later T stage (P ​= ​0.027) and clinical stage (P ​= ​0.014). The levels of energy intake (P ​= ​0.033), serum prealbumin (P ​< ​0.001), albumin (P ​= ​0.017) and hemoglobin (P ​= ​0.015) before treatment in NG group were significantly lower than those in oral intake group. Furthermore, patient-generated subjective global assessment (PG-SGA) score (P ​= ​0.016) and the levels of serum C-reactive protein (P ​= ​0.014) of NG feeding group were significantly higher than those of oral intake group. However, at the end of treatment, PG-SGA scores were increased in oral intake group and decreased in NG feeding group. In addition, the NG feeding group had a lower incidence of grade ≥2 esophagitis (P ​= ​0.037), and higher completion rate of chemotherapy compared with oral intake group (P ​= ​0.034). Meanwhile, the proportion of parenteral nutrition (P ​= ​0.008) and anti-inflammatory (P ​= ​0.022) treatment in NG feeding group was significantly lower than that in oral intake group. Although patients in the NG feeding group had a worse prognosis, there were no statistically significant differences in overall survival (OS) and progression-free survival (PFS) between the two groups (P ​> ​0.05).

Conclusions

As a safe and effective enteral nutrition approach to improving nutrition, nasogastric tube feeding could increase treatment completion rate and reduce the incidence of ≥ grade 2 esophagitis reaction during neoadjuvant chemoradiotherapy.

食管癌症新辅助同期放化疗中鼻肠管进食的优势:回顾性研究
目的比较食管鳞状细胞癌(ESCC)患者新辅助放化疗期间口服和鼻胃管喂养对患者营养状况、并发症及生存的影响。方法选取2018年12月至2020年3月接受新辅助放化疗的ESCC患者61例,其中口服摄入组38例,NG喂养组22例。收集两组患者的疾病特征和基线营养指标。观察两组患者的营养状况、并发症及放化疗完成率。结果与口服摄食组比较,NG喂养组患者T期(P = 0.027)和临床期(P = 0.014)均较口服摄食组晚。能量摄入水平(P = 0.033)、血清前白蛋白水平(P <NG组治疗前白蛋白(P = 0.017)、血红蛋白(P = 0.015)均显著低于口服摄入组。此外,NG饲喂组患者主观总体评价(PG-SGA)评分(P = 0.016)和血清c反应蛋白水平(P = 0.014)显著高于口服摄入组。治疗结束时,口服摄食组PG-SGA评分升高,NG摄食组PG-SGA评分降低。此外,与口服摄入组相比,NG喂养组≥2级食管炎发生率更低(P = 0.037),化疗完成率更高(P = 0.034)。同时,NG喂养组的肠外营养(P = 0.008)和抗炎(P = 0.022)治疗比例显著低于口服摄入组。虽然NG喂养组患者预后较差,但两组患者的总生存期(OS)和无进展生存期(PFS)差异无统计学意义(P >0.05)。结论鼻胃管喂养是一种安全有效的改善营养的肠内营养方式,可提高治疗完成率,降低新辅助放化疗中≥2级食管炎反应的发生率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Radiation Medicine and Protection
Radiation Medicine and Protection Health Professions-Emergency Medical Services
CiteScore
2.10
自引率
0.00%
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0
审稿时长
103 days
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