Gestational weight gain in women with type 1 and type 2 diabetes mellitus is related to both general and diabetes-related clinical characteristics.

IF 2.4 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormones-International Journal of Endocrinology and Metabolism Pub Date : 2024-03-01 Epub Date: 2023-10-16 DOI:10.1007/s42000-023-00497-9

Xinglei Xie, Jiaming Liu, Apolonia García-Patterson, Ana Chico, Manel Mateu-Salat, Judit Amigó, Juan María Adelantado, Rosa Corcoy

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Abstract

Purpose: To assess predictors of gestational weight gain (GWG), according to the Institute of Medicine (IOM) 2009, in women with type 1 and type 2 diabetes.

Methods: This was a retrospective cohort study conducted at a tertiary center. GWG based on the IOM was assessed both uncorrected and corrected for gestational age. General and diabetes-related clinical characteristics were analyzed as predictors.

Results: We evaluated 633 pregnant women with type 1 and type 2 diabetes. GWG uncorrected for gestational age was inadequate (iGWG) in 20.4%, adequate in 37.1%, and excessive (eGWG) in 42.5% of the women. Predictors included general (height, prepregnancy body mass index category, and multiple pregnancy) and diabetes-related clinical characteristics. Neuropathy and follow-up length were associated with iGWG (odds ratio (OR) 3.00, 95% CI 1.22-7.37; OR 0.92, 95% CI 0.86-0.97, respectively), while pump use and third-trimester insulin dose were associated with eGWG (OR 1.68, 95% CI 1.07-2.66; OR 3.64, 95% CI 1.88-7.06, respectively). Independent predictors for corrected GWG and sensitivity analyses also included general and diabetes-related clinical characteristics.

Conclusion: In this cohort of women with type 1 and type 2 diabetes, non-adequate GWG was common, mainly due to eGWG, and associated clinical characteristics were both general and diabetes-related. Current clinical care of these women during pregnancy may favor weight gain.

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1型和2型糖尿病妇女妊娠期体重增加与一般和糖尿病相关的临床特征有关。

目的：根据2009年医学研究所（IOM）的数据，评估1型和2型糖尿病女性妊娠期体重增加（GWG）的预测因素。方法：这是一项在三级中心进行的回顾性队列研究。基于IOM的GWG评估了未校正和校正的胎龄。分析了一般和糖尿病相关的临床特征作为预测因素。结果：我们评估了633名患有1型和2型糖尿病的孕妇。未经胎龄校正的GWG不足（iGWG）占20.4%，充足（37.1%）和过量（eGWG）分别占42.5%。预测因素包括一般（身高、孕前体重指数类别和多胎妊娠）和糖尿病相关的临床特征。神经病变和随访时间与iGWG相关（比值比（OR）3.00，95%CI 1.22-7.37；OR分别为0.92，95%CI分别为0.86-0.97），而泵吸使用和妊娠晚期胰岛素剂量与eGWG相关（OR分别为1.68，95%CI 1.07-2.66；OR分别为3.64，95%CI 1.88-7.06）。校正GWG和敏感性分析的独立预测因素还包括一般和糖尿病相关的临床特征。结论：在这一1型和2型糖尿病女性队列中，GWG不足是常见的，主要是由于eGWG，相关的临床特征既有一般性的，也有糖尿病相关的。目前这些妇女在怀孕期间的临床护理可能有利于体重增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormones-International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hormones-International Journal of Endocrinology and Metabolism is an international journal published quarterly with an international editorial board aiming at providing a forum covering all fields of endocrinology and metabolic disorders such as disruption of glucose homeostasis (diabetes mellitus), impaired homeostasis of plasma lipids (dyslipidemia), the disorder of bone metabolism (osteoporosis), disturbances of endocrine function and reproductive capacity of women and men. Hormones-International Journal of Endocrinology and Metabolism particularly encourages clinical, translational and basic science submissions in the areas of endocrine cancers, nutrition, obesity and metabolic disorders, quality of life of endocrine diseases, epidemiology of endocrine and metabolic disorders.