Pharmacological treatment for challenging behavior in adults with intellectual disability: Systematic review and meta-analysis.

IF 5.2 3区医学 Q1 PSYCHIATRY

Revista de psiquiatria y salud mental Pub Date : 2023-01-31 DOI:10.1016/j.rpsm.2023.01.003

Rodrigo Campos-Jara, Cristian Martínez-Salazar, Christian Campos-Jara, José María Fernández, Darío Martínez-García, Falonn Contreras-Osorio

{"title":"Pharmacological treatment for challenging behavior in adults with intellectual disability: Systematic review and meta-analysis.","authors":"Rodrigo Campos-Jara, Cristian Martínez-Salazar, Christian Campos-Jara, José María Fernández, Darío Martínez-García, Falonn Contreras-Osorio","doi":"10.1016/j.rpsm.2023.01.003","DOIUrl":null,"url":null,"abstract":"Introduction: Few evidence on the use of antipsychotics in people with intellectual disabilities and challenging behaviors, generates the need to develop studies that contribute to collect, compare and synthesize the available information. The present systematic review and meta-analysis aims to determine the clinical efficacy of antipsychotic medication in reducing critical episodes in this population.Methods: We searched Web of Science, Scopus, EBSCO, Embase, and PubMed for randomized controlled trials of antipsychotic medication versus placebo. Preliminarily yielded 1354 abstracts and citations; six studies with 274 subjects met the inclusion criteria of studies with experimental design, longitudinal type, with pre- and post-intervention measurements.Results: There is evidence for the use of psychotropic drugs in the acute management of challenging behaviors in patients with intellectual disability (SMD=-0.85; 95% CI=-1.69 to -0.01; p=0.05).Conclusions: Our results coincide with the recommendations on the efficacy of the use of antipsychotics. Although our study provides evidence, the limited number of studies included in this research does not allow us to obtain totally conclusive results, although it can be considered as a guide for future studies.","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":5.2000,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista de psiquiatria y salud mental","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.rpsm.2023.01.003","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Few evidence on the use of antipsychotics in people with intellectual disabilities and challenging behaviors, generates the need to develop studies that contribute to collect, compare and synthesize the available information. The present systematic review and meta-analysis aims to determine the clinical efficacy of antipsychotic medication in reducing critical episodes in this population.

Methods: We searched Web of Science, Scopus, EBSCO, Embase, and PubMed for randomized controlled trials of antipsychotic medication versus placebo. Preliminarily yielded 1354 abstracts and citations; six studies with 274 subjects met the inclusion criteria of studies with experimental design, longitudinal type, with pre- and post-intervention measurements.

Results: There is evidence for the use of psychotropic drugs in the acute management of challenging behaviors in patients with intellectual disability (SMD=-0.85; 95% CI=-1.69 to -0.01; p=0.05).

Conclusions: Our results coincide with the recommendations on the efficacy of the use of antipsychotics. Although our study provides evidence, the limited number of studies included in this research does not allow us to obtain totally conclusive results, although it can be considered as a guide for future studies.

查看原文本刊更多论文

成人智力残疾挑战行为的药理学治疗：系统综述和荟萃分析。

引言：关于在智障和有挑战性行为的人中使用抗精神病药物的证据很少，因此需要开展有助于收集、比较和综合现有信息的研究。本系统综述和荟萃分析旨在确定抗精神病药物在减少该人群危重发作方面的临床疗效。方法：我们在Web of Science、Scopus、EBSCO、Embase和PubMed上搜索抗精神病药物与安慰剂的随机对照试验。初步产生1354篇摘要和引文；6项涉及274名受试者的研究符合实验设计、纵向类型、干预前后测量的纳入标准。结果：有证据表明精神药物用于智力残疾患者挑战行为的急性管理（SMD=-0.85；95%CI=1.69-0.01；p=0.05）。结论：我们的结果与关于使用抗精神病药物疗效的建议一致。尽管我们的研究提供了证据，但这项研究中包含的研究数量有限，无法使我们获得完全结论性的结果，尽管它可以被视为未来研究的指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revista de psiquiatria y salud mental PSYCHIATRY-

自引率

3.30%

发文量

期刊介绍： The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.

文献相关原料

公司名称	产品信息	采购帮参考价格