Association Between Psychosocial Stress and Brain Aging: Results of the Population-Based Cohort Study of Health in Pomerania (SHIP).

IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY
Francisca S Rodriguez, Hans J Grabe, Stefan Frenzel, Johanna Klinger-König, Robin Bülow, Henry Völzke, Wolfgang Hoffmann
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引用次数: 0

Abstract

Objective: Recent studies suggest that psychosocial factors can have an impact on brain health. Yet, it is unclear whether psychosocial stress affects aging of the brain. The aim of the study was to investigate the association between psychosocial stress and brain aging.

Methods: Data from the German population-based cohort Study of Health in Pomerania (N=991; age range 20-78 years) were used to calculate a total psychosocial stress score by combining subscores from five domains: stress related to the living situation, the occupational situation, the social situation, danger experiences, and emotions. Associations with brain aging, indicated by an MRI-derived score quantifying age-related brain atrophy, were estimated by using regression models adjusted for age, gender, education, diabetes, problematic alcohol consumption, smoking, and hypertension.

Results: The relative risk ratio for advanced brain aging was 1.21 (95% CI=1.04-1.41) for stress related to emotions in fully adjusted models. The interactions between stress related to emotions and mental health symptoms were also significantly associated with advanced brain aging. The association between higher total psychosocial stress and brain aging was not statistically significant.

Conclusions: These findings highlight that high stress related to emotions is associated with advanced brain aging. To protect brain health in older age, more research is needed to explore the role of emotional distress.

心理社会压力和大脑衰老之间的关系:波美拉尼亚(SHIP)基于人群的健康队列研究结果。
目的:最近的研究表明,心理社会因素会对大脑健康产生影响。然而,目前尚不清楚心理社会压力是否会影响大脑的衰老。这项研究的目的是调查心理社会压力与大脑衰老之间的关系。方法:使用来自德国波美拉尼亚健康人群队列研究(N=991;年龄范围20-78岁)的数据,通过合并五个领域的分量表来计算心理社会压力总分:与生活状况、职业状况、社会状况、危险经历和情绪相关的压力。通过使用根据年龄、性别、教育程度、糖尿病、有问题的饮酒、吸烟和高血压调整的回归模型,估计了与大脑衰老的关系,该关系由量化与年龄相关的脑萎缩的MRI衍生评分表示。结果:在完全调整的模型中,与情绪相关的压力导致晚期大脑衰老的相对风险比为1.21(95%CI=1.04-1.41)。与情绪相关的压力和心理健康症状之间的相互作用也与晚期大脑衰老显著相关。较高的总心理社会压力与大脑衰老之间的相关性没有统计学意义。结论:这些发现强调了与情绪相关的高压力与晚期大脑衰老有关。为了保护老年人的大脑健康,需要更多的研究来探索情绪困扰的作用。
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来源期刊
CiteScore
5.30
自引率
3.40%
发文量
67
审稿时长
6-12 weeks
期刊介绍: As the official Journal of the American Neuropsychiatric Association, the premier North American organization of clinicians, scientists, and educators specializing in behavioral neurology & neuropsychiatry, neuropsychology, and the clinical neurosciences, the Journal of Neuropsychiatry and Clinical Neurosciences (JNCN) aims to publish works that advance the science of brain-behavior relationships, the care of persons and families affected by neurodevelopmental, acquired neurological, and neurodegenerative conditions, and education and training in behavioral neurology & neuropsychiatry. JNCN publishes peer-reviewed articles on the cognitive, emotional, and behavioral manifestations of neurological conditions, the structural and functional neuroanatomy of idiopathic psychiatric disorders, and the clinical and educational applications and public health implications of scientific advances in these areas. The Journal features systematic reviews and meta-analyses, narrative reviews, original research articles, scholarly considerations of treatment and educational challenges in behavioral neurology & neuropsychiatry, analyses and commentaries on advances and emerging trends in the field, international perspectives on neuropsychiatry, opinions and introspections, case reports that inform on the structural and functional bases of neuropsychiatric conditions, and classic pieces from the field’s rich history.
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