Celochalcoside, a new quinochalcone C-glycoside from Celosia trigyna

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-03 DOI:10.1080/10286020.2023.2269528

Samy K. El-Desouky

引用次数: 0

Abstract

A new quinochalcone C-glycoside featuring a unique quinonoid moiety, named celochalcoside (1), was isolated from the n-butanol extract of the aerial parts of Celosia trigyna L. The structure was determined by extensive spectroscopic analysis as well as mass spectrometric data. Compound 1 showed moderate cytotoxic activities against breast cancer cell lines (MCF-7), colon cancer cell lines (HT-29) and hepatocellular carcinoma cell lines (HepG2) with IC₅₀ values of 23.16, 37.05 and 18.35 μg/ml, respectively.

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三棱青藤中一种新的醌查尔酮C-糖苷。

从三角青藤地上部分的正丁醇提取物中分离到一种新的醌查尔酮C-糖苷，具有独特的醌类结构，命名为青藤醇苷（1）。通过广泛的光谱分析和质谱数据确定了其结构。化合物1对乳腺癌症细胞系（MCF-7）、癌症结肠癌细胞系（HT-29）和肝细胞癌细胞系（HepG2）表现出中等的细胞毒性活性，IC50值分别为23.16、37.05和18.35 μg/ml。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.