Exploring the Potential of Natural Products as Antiparasitic Agents for Neglected Tropical Diseases.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0115680266256963230921061925

Dayanna Orosco, Arturo René Mendoza, Carlos Mario Meléndez

引用次数: 0

Abstract

Recent developments in the use of natural product-based molecules as antiparasitic agents for Malaria, leishmaniasis (LE), Chagas disease (CD), and Human African trypanosomiasis (HAT) are reviewed. The role of diverse plants in developing bioactive species is discussed in addition to analyzing the structural diversity of natural products as active agents and the diverse biological applications in CD, HAT, LE, and Malaria. This review focuses on medicinal chemistry, emphasizing the structural characteristics of natural molecules as bioactive agents against parasitic infections caused by Leishmania, Trypanosoma, and Plasmodium parasites.

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探索天然产品作为被忽视的热带疾病的抗寄生虫剂的潜力。

综述了基于天然产物的分子作为抗寄生虫剂治疗疟疾、利什曼病（LE）、查加斯病（CD）和非洲锥虫病（HAT）的最新进展。除了分析作为活性剂的天然产物的结构多样性以及在CD、HAT、LE和疟疾中的不同生物学应用外，还讨论了不同植物在开发生物活性物种中的作用。这篇综述的重点是药物化学，强调天然分子作为生物活性剂对抗由利什曼原虫、锥虫和疟原虫引起的寄生虫感染的结构特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.