Microfluidic paper-based analytical device integrated with Fe@ZnS:MIP for colorimetric detection of antibiotics

IF 3.674 4区工程技术 Q1 Engineering

Applied Nanoscience Pub Date : 2023-07-04 DOI:10.1007/s13204-023-02920-4

Ahsan Riaz, Iqra Zareef, Anam Munawar, Allah Rakha, Muhammad Farhan Khan, Sareen Akhtar, Amna Anwar, Shahid Nazir, Salah ud Din, Ahtisham Shuja Abbasi

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引用次数: 0

Abstract

Persistence and misuse of antibiotics eventually give rise to the progression of resistance development in bacteria. Consequently, accurate, fast and cost-effective sensing devices are required to govern the presence of drugs. Herein, we design a microfluidic paper-based device (μPAD) for the detection of Rifampicin. We selected this analyte because of its persistent overuse for the treatment of tuberculosis, among the major causes of death around the world. In this work, we have integrated Fe-reinforced ZnS nanoparticles supported with rifampicin (RIF) imprinted material on the exterior of Whatman filter paper for the fabrication of paper-based microfluidic device (μPAD). In this fabricated μPAD colorimetric detection was performed, and the synergistic effect of Fe and ZnS was recorded as compared to individual nanomaterials. A distinct color indicator was used to quantify the concentration of the targeted substance by the naked eye. The fabricated paper-based sensor possessed high sensitivity for rifampicin detection, recorded linear calibration curve representing 0.1 µM LOD and excellent selectivity, in comparison to other inferring agents present in real samples. The practical application of this designed μPAD was validated by applying a real sample.

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微流控纸基分析装置与Fe@ZnS：MIP用于抗生素的比色检测

抗生素的持续使用和滥用最终导致细菌耐药性的发展。因此，需要准确、快速和具有成本效益的传感设备来控制药物的存在。在此，我们设计了一种用于检测利福平的微流控纸基装置（μPAD）。我们之所以选择这种分析物，是因为它在治疗结核病方面持续过度使用，而结核病是世界各地死亡的主要原因之一。在这项工作中，我们在Whatman滤纸的外部集成了用利福平（RIF）印迹材料支撑的铁增强ZnS纳米颗粒，用于制造纸基微流体装置（μPAD）。在这种制造的μPAD比色检测中，与单个纳米材料相比，记录了Fe和ZnS的协同效应。使用不同的颜色指示剂通过肉眼来量化目标物质的浓度。与真实样品中存在的其他推断试剂相比，所制造的纸基传感器对利福平检测具有高灵敏度，记录的线性校准曲线代表0.1µM LOD和优异的选择性。μPAD在实际应用中得到了验证。

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来源期刊

Applied Nanoscience Materials Science-Materials Science (miscellaneous)

CiteScore

7.10

自引率

0.00%

发文量

430

期刊介绍： Applied Nanoscience is a hybrid journal that publishes original articles about state of the art nanoscience and the application of emerging nanotechnologies to areas fundamental to building technologically advanced and sustainable civilization, including areas as diverse as water science, advanced materials, energy, electronics, environmental science and medicine. The journal accepts original and review articles as well as book reviews for publication. All the manuscripts are single-blind peer-reviewed for scientific quality and acceptance.