3D printing-based full-scale human brain for diverse applications

Brain-X Pub Date : 2023-04-05 DOI:10.1002/brx2.5
Weijian Hua, Cheng Zhang, Lily Raymond, Kellen Mitchell, Lai Wen, Ying Yang, Danyang Zhao, Shu Liu, Yifei Jin
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Abstract

Surgery is the most frequent treatment for patients with brain tumors. The construction of full-scale human brain models, which is still challenging to realize via current manufacturing techniques, can effectively train surgeons before brain tumor surgeries. This paper aims to develop a set of three-dimensional (3D) printing approaches to fabricate customized full-scale human brain models for surgery training as well as specialized brain patches for wound healing after surgery. First, a brain patch designed to fit a wound's shape and size can be easily printed in and collected from a stimuli-responsive yield-stress support bath. Then, an inverse 3D printing strategy, called “peeling-boiled-eggs,” is proposed to fabricate full-scale human brain models. In this strategy, the contour layer of a brain model is printed using a sacrificial ink to envelop the target brain core within a photocurable yield-stress support bath. After crosslinking the contour layer, the as-printed model can be harvested from the bath to photo crosslink the brain core, which can be eventually released by liquefying the contour layer. Both the brain patch and full-scale human brain model are successfully printed to mimic the scenario of wound healing after removing a brain tumor, validating the effectiveness of the proposed 3D printing approaches.

Abstract Image

基于3D打印的全尺寸人脑,适用于各种应用。
手术是脑肿瘤患者最常见的治疗方法。通过目前的制造技术,全尺寸人脑模型的构建仍然具有挑战性,可以在脑瘤手术前有效地培训外科医生。本文旨在开发一套三维(3D)打印方法,以制作用于手术训练的定制全尺寸人脑模型,以及用于术后伤口愈合的专用脑补片。首先,设计用于适应伤口形状和大小的脑补片可以很容易地打印出来,并从刺激反应性屈服-压力支持浴中收集。然后,提出了一种反向3D打印策略,称为“剥煮鸡蛋”,以制造全尺寸的人脑模型。在这种策略中,使用牺牲墨水打印大脑模型的轮廓层,以将目标大脑核心包裹在光固化屈服应力支撑浴中。在交联轮廓层之后,可以从浴中获得打印好的模型,以光交联脑核心,最终可以通过液化轮廓层来释放脑核心。大脑贴片和全尺寸人脑模型都被成功打印出来,以模拟切除脑瘤后伤口愈合的场景,验证了所提出的3D打印方法的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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