Comparison between the European Randomized Study for Screening of Prostate Cancer (ERSPC) and Prostate Biopsy Collaborative Group (PBCG) risk calculators: Prediction of clinically significant Prostate Cancer risk in a cohort of patients from Argentina

P.M. Orbe Villota , J.A. Leiva Centeno , J. Lugones , P.G. Minuzzi , S.M. Varea
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Abstract

Objective

To compare the performance of the risk calculators of the European Randomized Study for Screening of Prostate Cancer (ERSPC) and the Prostate Biopsy Collaborative Group (PBCG) in predicting the risk of presenting clinically significant prostate cancer.

Material and methods

Retrospectively, patients who underwent prostate biopsy at Sanatorio Allende Cerro, Ciudad de Córdoba, Argentina, were identified from January 2018 to December 2021. The probability of having prostate cancer was calculated with the two calculators separately and then the results were compared to establish which of the two performed better. For this, areas under the curve (AUC) were analyzed.

Results

250 patients were included, 140 (56%) presented prostate cancer, of which 92 (65.71%) had clinically significant prostate cancer (Gleason score ≥7). The patients who presented cancer were older, had a higher prostate-specific antigen (PSA) value, and had a smaller prostate size. The AUC to predict the probability of having clinically significant prostate cancer was 0.79 and 0.73 for PBCG-RC and ERSPC-RC respectively (P = 0.0084).

Conclusion

In this cohort of patients, both prostate cancer risk calculators performed well in predicting clinically significant prostate cancer risk, although the PBCG-RC showed better accuracy.

欧洲癌症筛查随机研究(ERSPC)与前列腺活检协作组(PBCG)风险计算器的比较:阿根廷患者队列中具有临床意义的癌症风险预测。
目的:比较欧洲癌症筛查随机研究(ERSPC)和前列腺活检协作小组(PBCG)的风险计算器在预测临床显著前列腺癌症风险方面的性能。材料和方法:回顾性分析,2018年1月至2021年12月,在阿根廷科尔多瓦城Sanatorio Allende Cerro接受前列腺活检的患者。分别用两个计算器计算患前列腺癌症的概率,然后将结果进行比较,以确定两者中哪一个表现更好。为此,分析了曲线下面积(AUC)。结果:纳入患者250例,其中140例(56%)为前列腺癌,其中92例(65.71%)为有临床意义的癌症(Gleason评分≥7)。癌症患者年龄较大,前列腺特异性抗原(PSA)值较高,前列腺大小较小。PBCG-RC和ERSPC-RC预测具有临床意义的前列腺癌症概率的AUC分别为0.79和0.73(P = .0084)。结论:在这组患者中,两种前列腺癌症风险计算器在预测临床显著的前列腺癌症风险方面都表现良好,尽管PBCG-RC显示出更好的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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