FTO variation and early frontostriatal brain development in children

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2023-10-10 DOI:10.1002/oby.23926

Gita Thapaliya, Poorbita Kundu, Elena Jansen, Marcus A. Naymik, Richard Lee, Muriel Marisa Katharina Bruchhage, Viren D'Sa, Matthew J. Huentelman, Candace R. Lewis, Hans-Georg Müller, Sean C. L. Deoni, RESONANCE consortium, Susan Carnell

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引用次数: 0

Abstract

Objective

Common obesity-associated genetic variants at the fat mass and obesity-associated (FTO) locus have been associated with appetitive behaviors and altered structure and function of frontostriatal brain regions. The authors aimed to investigate the influence of FTO variation on frontostriatal appetite circuits in early life.

Methods

Data were drawn from RESONANCE, a longitudinal study of early brain development. Growth trajectories of nucleus accumbens and frontal lobe volumes, as well as total gray matter and white matter volume, by risk allele (AA) carrier status on FTO single-nucleotide polymorphism rs9939609 were examined in 228 children (102 female, 126 male) using magnetic resonance imaging assessments obtained from infancy through middle childhood. The authors fit functional concurrent regression models with brain volume outcomes over age as functional responses, and FTO genotype, sex, BMI z score, and maternal education were included as predictors.

Results

Bootstrap pointwise 95% CI for regression coefficient functions in the functional concurrent regression models showed that the AA group versus the group with no risk allele (TT) had greater nucleus accumbens volume (adjusted for total brain volume) in the interval of 750 to 2250 days (2–6 years).

Conclusions

These findings suggest that common genetic risk for obesity is associated with differences in early development of brain reward circuitry and argue for investigating dynamic relationships among genotype, brain, behavior, and weight throughout development.

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FTO变异与儿童额纹状体早期大脑发育。

目的：脂肪量和肥胖相关（FTO）基因座常见的肥胖相关基因变异与食欲行为以及额纹状体脑区结构和功能的改变有关。作者旨在研究FTO变化对早期生活中额腹食欲回路的影响。方法：数据来源于RESONCE，一项关于早期大脑发育的纵向研究。根据FTO单核苷酸多态性rs9939609的风险等位基因（AA）携带者状态，对228名儿童（102 女性，126 男性）使用从婴儿期到儿童中期获得的磁共振成像评估。作者拟合了功能并发回归模型，将随年龄增长的脑容量结果作为功能反应，FTO基因型、性别、BMI z评分和母亲教育程度作为预测因素。结果：功能并发回归模型中回归系数函数的Bootstrap逐点95%置信区间显示，AA组与没有风险等位基因（TT）的组相比，在750至2250的区间内伏隔核体积（经总脑体积调整）更大天（2-6 结论：这些发现表明，肥胖的常见遗传风险与大脑奖赏回路早期发育的差异有关，并有理由在整个发育过程中研究基因型、大脑、行为和体重之间的动态关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.