Bioinformatics analysis of the potential mechanisms of Alzheimer's disease induced by exposure to combined triazine herbicides.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2023-02-01 Epub Date: 2023-10-11 DOI:10.1080/03014460.2023.2259242

Jianan Li, Ling Qi, Yuxin Chen, Haoming Lv, Haoran Bi

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引用次数: 0

Abstract

Background: The development of Alzheimer's disease (AD) is promoted by a combination of genetic and environmental factors. Notably, combined exposure to triazine herbicides atrazine (ATR), simazine (SIM), and propazine (PRO) may promote the development of AD, but the mechanism is unknown.

Aim: To study the molecular mechanism of AD induced by triazine herbicides.

Methods: Differentially expressed genes (DEGs) of AD patients and controls were identified. The intersectional targets of ATR, SIM, and PRO for possible associations with AD were screened through network pharmacology and used for gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analysis. The binding potentials between the core targets and herbicides were validated by molecular docking and molecular dynamics.

Results: A total of 1,062 DEGs were screened between the AD patients and controls, which identified 148 intersectional targets of herbicides causing AD that were screened by network pharmacology analysis. GO and KEGG enrichment analysis revealed that cell cycling and cellular senescence were important signalling pathways. Finally, the core targets EGFR, FN1, and TYMS were screened and validated by molecular docking and molecular dynamics.

Conclusion: Our results suggest that combined exposure to triazine herbicides might promote the development of AD, thereby providing new insights for the prevention of AD.

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接触三嗪类除草剂诱发阿尔茨海默病潜在机制的生物信息学分析。

背景：阿尔茨海默病（AD）的发展是由遗传和环境因素共同推动的。值得注意的是，联合暴露于三嗪类除草剂阿特拉津（ATR）、西马嗪（SIM）和丙嗪（PRO）可能会促进AD的发展，但其机制尚不清楚。目的：研究三嗪类除草剂诱发AD的分子机制。方法：对AD患者和对照组的差异表达基因（DEGs）进行鉴定。通过网络药理学筛选ATR、SIM和PRO可能与AD相关的交叉靶标，并用于基因本体论（GO）和京都基因和基因组百科全书（KEGG）富集分析。通过分子对接和分子动力学验证了核心靶标与除草剂之间的结合潜力。结果：AD患者和对照组共筛选出1062个DEG，通过网络药理学分析筛选出148个除草剂引起AD的交叉靶标。GO和KEGG富集分析表明，细胞周期和细胞衰老是重要的信号通路。最后，通过分子对接和分子动力学对核心靶点EGFR、FN1和TYMS进行了筛选和验证。结论：三嗪类除草剂联合暴露可能促进AD的发展，为AD的预防提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.