Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research.

IF 5.3 2区医学

Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-10-13 DOI:10.1007/s11914-023-00821-7

Serra Kaya, Tamara Alliston, Daniel S Evans

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引用次数: 0

Abstract

Purpose of review: The integration of data from multiple genomic assays from humans and non-human model organisms is an effective approach to identify genes involved in skeletal fragility and fracture risk due to osteoporosis and other conditions. This review summarizes genome-wide genetic variation and gene expression data resources relevant to the discovery of genes contributing to skeletal fragility and fracture risk.

Recent findings: Genome-wide association studies (GWAS) of osteoporosis-related traits are summarized, in addition to gene expression in bone tissues in humans and non-human organisms, with a focus on rodent models related to skeletal fragility and fracture risk. Gene discovery approaches using these genomic data resources are described. We also describe the Musculoskeletal Knowledge Portal (MSKKP) that integrates much of the available genomic data relevant to fracture risk. The available genomic resources provide a wealth of knowledge and can be analyzed to identify genes related to fracture risk. Genomic resources that would fill particular scientific gaps are discussed.

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用于骨质疏松症和骨生物学研究的遗传和基因表达资源。

综述目的：整合来自人类和非人类模式生物的多个基因组分析的数据是识别与骨质疏松症和其他疾病导致的骨骼脆弱性和骨折风险有关的基因的有效方法。本文综述了与发现导致骨骼脆弱性和骨折风险的基因相关的全基因组遗传变异和基因表达数据资源。最近的发现：除了人类和非人类生物体骨组织中的基因表达外，还总结了骨质疏松症相关特征的全基因组关联研究（GWAS），重点是与骨骼脆弱性和骨折风险相关的啮齿动物模型。描述了使用这些基因组数据资源的基因发现方法。我们还描述了肌肉骨骼知识门户（MSKKP），该门户整合了许多与骨折风险相关的可用基因组数据。现有的基因组资源提供了丰富的知识，可以进行分析以确定与骨折风险相关的基因。讨论了填补特定科学空白的基因组资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.