Fifty Years of Diazeniumdiolate Research: A Tribute to Dr. Larry K. Keefer.

Q4 Biochemistry, Genetics and Molecular Biology

Critical Reviews in Oncogenesis Pub Date : 2023-01-01 DOI:10.1615/CritRevOncog.2023048491

Khosrow Kashfi

引用次数: 0

Abstract

The pioneering studies of Dr. Larry Keefer and colleagues with diazeniumdiolates or NONOates as a platform have unraveled the chemical biology of many nitric oxides and have led to the design of a variety of promising therapeutic agents in oncology, gastroenterology, antimicrobials, wound healing, and the like. This dedication to Dr. Larry Keefer briefly highlights some of his studies using the diazeniumdiolate platform in the cancer arena.

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二酸二氮鎓研究五十年：向拉里·K·基弗博士致敬。

Larry Keefer博士及其同事以二醇二氮鎓或NONOates为平台进行的开创性研究揭示了许多一氧化氮的化学生物学，并在肿瘤学、胃肠病学、抗菌剂、伤口愈合等领域设计出了各种有前景的治疗剂。这份对Larry Keefer博士的奉献简要强调了他在癌症领域使用二氮烯鎓二醇酯平台的一些研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Oncogenesis Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.