The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study.

IF 2.6 4区医学 Q2 HEMATOLOGY

Thrombosis Journal Pub Date : 2023-10-13 DOI:10.1186/s12959-023-00551-x

Pengcheng Xu, Shouqing Han, Ming Hou, Yajing Zhao, Miao Xu

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引用次数: 0

Abstract

Background: Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by increased platelet destruction and impaired thrombopoiesis. The changes in platelet indices depend on the morphology and volume of platelets. Serum lipids have been found to affect platelet formation and activity in certain diseases, thus inducing the corresponding variation of platelet indices.

Methods: Mendelian randomization (MR) analysis was performed based on databases. The clinical data from 457 ITP patients were retrospectively collected and analyzed, including platelet indices, serum lipids, hemorrhages and therapeutic responses.

Results: MR analysis showed low high-density-lipoprotein-cholesterol (HDL-C), low apolipoprotein A-1, high triglyceride (TG) and high apolipoprotein B (ApoB) caused high platelet distribution width (PDW); high low-density-lipoprotein-cholesterol (LDL-C) increased mean platelet volume (MPV). In ITP, there were positive correlations between platelet count with TG, PDW with HDL-C and ApoB, and plateletcrit with TG and non-esterified fatty acid, and the correlation had gender differences. Bleeding scores were negatively correlated with cholesterol and LDL-C. LDL-C and homocysteine were risk factors for therapeutic responses.

Conclusions: Serum lipids, especially cholesterol were tightly correlated with platelet indices, hemorrhage and therapeutic effects in ITP patients. These results provide clinical references for the management of serum lipids, and highlight the necessity to further explore the relationship between lipids and pathogenesis of ITP.

Trial registration: No: NCT05095896, October 14, 2021, retrospectively registered.

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免疫性血小板减少症的血脂谱：孟德尔随机化分析和回顾性研究。

背景：免疫性血小板减少症（ITP）是一种自身免疫性出血性疾病，其特征是血小板破坏增加和血小板生成受损。血小板指数的变化取决于血小板的形态和体积。在某些疾病中，血脂会影响血小板的形成和活性，从而导致血小板指数的相应变化。方法：基于数据库进行孟德尔随机化（MR）分析。对457例ITP患者的临床数据进行回顾性收集和分析，包括血小板指数、血脂、出血和治疗反应。结果：MR分析显示，低高密度脂蛋白胆固醇（HDL-C）、低载脂蛋白A-1、高甘油三酯（TG）和高载脂蛋白B（ApoB）引起血小板分布宽度（PDW）增高；高密度脂蛋白胆固醇（LDL-C）使平均血小板体积（MPV）增加。ITP中，血小板计数与TG呈正相关，PDW与HDL-C和ApoB呈正相关，血小板比容与TG和非酯化脂肪酸呈正相关，且相关性存在性别差异。出血评分与胆固醇和低密度脂蛋白胆固醇呈负相关。LDL-C和同型半胱氨酸是治疗反应的危险因素。结论：ITP患者的血脂，尤其是胆固醇与血小板指数、出血量及疗效密切相关。这些结果为血脂的管理提供了临床参考，并强调了进一步探索脂质与ITP发病机制之间关系的必要性。试验注册号：NCT050958962021年10月14日，回顾性注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thrombosis Journal Medicine-Hematology

CiteScore

3.80

自引率

3.20%

发文量

审稿时长

16 weeks

期刊介绍： Thrombosis Journal is an open-access journal that publishes original articles on aspects of clinical and basic research, new methodology, case reports and reviews in the areas of thrombosis. Topics of particular interest include the diagnosis of arterial and venous thrombosis, new antithrombotic treatments, new developments in the understanding, diagnosis and treatments of atherosclerotic vessel disease, relations between haemostasis and vascular disease, hypertension, diabetes, immunology and obesity.

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