3D printing for bone regeneration: challenges and opportunities for achieving predictability.

IF 17.5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Periodontology 2000 Pub Date : 2023-10-01 Epub Date: 2023-10-12 DOI:10.1111/prd.12525
Saso Ivanovski, Omar Breik, Danilo Carluccio, Jamil Alayan, Ruben Staples, Cedryck Vaquette
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引用次数: 0

Abstract

3D printing offers attractive opportunities for large-volume bone regeneration in the oro-dental and craniofacial regions. This is enabled by the development of CAD-CAM technologies that support the design and manufacturing of anatomically accurate meshes and scaffolds. This review describes the main 3D-printing technologies utilized for the fabrication of these patient-matched devices, and reports on their pre-clinical and clinical performance including the occurrence of complications for vertical bone augmentation and craniofacial applications. Furthermore, the regulatory pathway for approval of these devices is discussed, highlighting the main hurdles and obstacles. Finally, the review elaborates on a variety of strategies for increasing bone regeneration capacity and explores the future of 4D bioprinting and biodegradable metal 3D printing.

骨骼再生的3D打印:实现可预测性的挑战和机遇。
3D打印为口腔和颅面区域的大体积骨再生提供了有吸引力的机会。这得益于CAD-CAM技术的发展,该技术支持解剖学精确网格和支架的设计和制造。这篇综述描述了用于制造这些患者匹配设备的主要3D打印技术,并报告了它们的临床前和临床性能,包括垂直骨增强和颅面应用并发症的发生。此外,还讨论了批准这些设备的监管途径,强调了主要障碍和障碍。最后,综述了提高骨再生能力的各种策略,并探讨了4D生物打印和可生物降解金属3D打印的未来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Periodontology 2000
Periodontology 2000 医学-牙科与口腔外科
CiteScore
34.10
自引率
2.20%
发文量
62
审稿时长
>12 weeks
期刊介绍: Periodontology 2000 is a series of monographs designed for periodontists and general practitioners interested in periodontics. The editorial board selects significant topics and distinguished scientists and clinicians for each monograph. Serving as a valuable supplement to existing periodontal journals, three monographs are published annually, contributing specialized insights to the field.
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