Early-life manganese exposure during multiple developmental periods and adolescent verbal learning and memory

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology Pub Date : 2023-11-01 DOI:10.1016/j.ntt.2023.107307

Alexa Friedman , Samantha Schildroth , Julia A. Bauer , Brent A. Coull , Donald R. Smith , Donatella Placidi , Giuseppa Cagna , Maxine H. Krengel , Yorghos Tripodis , Roberta F. White , Roberto G. Lucchini , Robert O. Wright , Megan Horton , Christine Austin , Manish Arora , Birgit Claus Henn

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引用次数: 0

Abstract

Background

Manganese (Mn) is both an essential and toxic metal, and associations with neurodevelopment depend on exposure timing. Prospective data examining early life Mn with adolescent cognition are sparse.

Methods

We enrolled 140 Italian adolescents (10–14 years old) from the Public Health Impact of Metals Exposure study. Mn in deciduous teeth was measured using laser ablation-mass spectrometry to represent prenatal, postnatal and early childhood exposure. The California Verbal Learning Test for Children (CVLT-C) was administered to assess adolescent verbal learning and memory. Multivariable regression models estimated changes in CVLT-C scores and the odds of making an error per doubling in dentine Mn in each exposure period. Multiple informant models tested for differences in associations across exposure periods.

Results

A doubling in prenatal dentine Mn levels was associated with lower odds of making an intrusion error (OR = 0.23 [95% CI: 0.09, 0.61]). This beneficial association was not observed in other exposure periods. A doubling in childhood Mn was beneficially associated with short delay free recall: (ß = 0.47 [95% CI: −0.02, 0.97]), which was stronger in males (ß = 0.94 [95% CI: 0.05, 1.82]). Associations were null in the postnatal period.

Conclusion

Exposure timing is critical for understanding Mn-associated changes in cognitive function.

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早期生活中多个发育窗口期的锰暴露以及青少年的言语学习和记忆。

背景：锰是一种必需的有毒金属，与神经发育的关系取决于接触时间。研究早期生活Mn与青少年认知的前瞻性数据很少。方法：我们招募了140名意大利青少年（10-14岁） 岁）。使用激光消融质谱法测量乳牙中的Mn，以代表产前、产后和儿童早期的暴露。加州儿童言语学习测试（CVLT-C）用于评估青少年的言语学习和记忆。多变量回归模型估计了CVLT-C评分的变化，以及每个暴露窗口中牙本质Mn每增加一倍出错的几率。多个线人模型测试了不同暴露窗口之间的关联差异。结果：产前牙本质Mn水平翻倍与发生侵入错误的几率较低有关（OR = 0.23[95%CI:0.09，0.61]）。在其他暴露窗口中没有观察到这种有益的关联。儿童Mn的翻倍与短时间无延迟回忆有益相关：（ß = 0.47[95%CI:0.02，0.97]），这在男性中更强（ß = 0.94[95%CI:0.05，1.82]）。结论：接触时间对于理解锰相关的认知功能变化至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurotoxicology and teratology 医学-毒理学

CiteScore

5.60

自引率

10.30%

发文量

审稿时长

58 days

期刊介绍： Neurotoxicology and Teratology provides a forum for publishing new information regarding the effects of chemical and physical agents on the developing, adult or aging nervous system. In this context, the fields of neurotoxicology and teratology include studies of agent-induced alterations of nervous system function, with a focus on behavioral outcomes and their underlying physiological and neurochemical mechanisms. The Journal publishes original, peer-reviewed Research Reports of experimental, clinical, and epidemiological studies that address the neurotoxicity and/or functional teratology of pesticides, solvents, heavy metals, nanomaterials, organometals, industrial compounds, mixtures, drugs of abuse, pharmaceuticals, animal and plant toxins, atmospheric reaction products, and physical agents such as radiation and noise. These reports include traditional mammalian neurotoxicology experiments, human studies, studies using non-mammalian animal models, and mechanistic studies in vivo or in vitro. Special Issues, Reviews, Commentaries, Meeting Reports, and Symposium Papers provide timely updates on areas that have reached a critical point of synthesis, on aspects of a scientific field undergoing rapid change, or on areas that present special methodological or interpretive problems. Theoretical Articles address concepts and potential mechanisms underlying actions of agents of interest in the nervous system. The Journal also publishes Brief Communications that concisely describe a new method, technique, apparatus, or experimental result.