Dietary and commensal yeasts drive aberrant T cell responses in Crohn’s disease

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2023-10-11 DOI:10.1038/s41591-023-02559-2

引用次数: 0

Abstract

Aberrant immune responses to the intestinal microbiome have emerged as major contributors to chronic intestinal inflammation, but the microbial species involved in inflammatory bowel diseases remain unknown. Our study identified dietary and commensal yeasts of the gut that drive the expansion of some cross-reactive CD4+ type 1 helper T cells with cytotoxic effector functions, which potentially contributes to immunopathology in patients with Crohn’s disease.

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在克罗恩病中，饮食和共生酵母驱动异常的T细胞反应。

肠道微生物组的异常免疫反应已成为慢性肠道炎症的主要诱因，但参与炎症性肠病的微生物种类仍不清楚。我们的研究发现，肠道中的膳食酵母菌和共生酵母菌会促使一些具有细胞毒性效应功能的交叉反应型 CD4+ 1 型辅助 T 细胞扩增，这可能会导致克罗恩病患者的免疫病理学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

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