Decreased oxidative stress response and oxidant detoxification of skin during aging

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2023-10-11 DOI:10.1016/j.mad.2023.111878

Xixia Dai, Yibo Hu, Ling Jiang, Li Lei, Chuhan Fu, Songjiang Wu, Xiaolin Zhang, Lu Zhu, Fan Zhang, Jing Chen, Qinghai Zeng

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引用次数: 0

Abstract

Oxidative stress plays an important role in the skin aging process; however, the mechanisms are not fully elucidated. Especially the changes in various types of skin cells with aging and the key oxidative stress-related genes that play a regulatory role are not clear. In this study, single-cell RNA sequencing data and microarray transcriptome data were used to explore the changes in oxidative stress response and oxidant detoxification capacity of skin cells during aging and oxidative stress-related genes potentially involved in regulating skin aging were searched. The oxidative stress response and oxidant detoxification ability were weakened in the elderly compared with those of the young. Among the different types of skin cells, keratinocytes, melanocytes, vascular endothelial cells, fibroblasts, and lymphatic endothelial cells exhibited a stronger oxidative stress response and oxidant detoxification ability, while immune cells exhibited a weaker oxidative stress response and detoxification capacity. During aging, the oxidative stress response and oxidant detoxification capacity of keratinocytes, fibroblasts, macrophages, and vascular endothelial cells were significantly weakened. Annexin A1 (ANXA1) and Apolipoprotein E (APOE) may be key oxidative stress-related genes affecting skin aging.

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在衰老过程中降低了皮肤的氧化应激反应和氧化解毒作用。

氧化应激在皮肤衰老过程中起着重要作用；然而，其机制尚未完全阐明。特别是各种类型的皮肤细胞随着衰老的变化以及发挥调节作用的关键氧化应激相关基因尚不清楚。在本研究中，使用单细胞RNA测序数据和微阵列转录组数据来探索皮肤细胞在衰老过程中氧化应激反应和氧化解毒能力的变化，并搜索可能参与调节皮肤衰老的氧化应激相关基因。与年轻人相比，老年人的氧化应激反应和氧化解毒能力减弱。在不同类型的皮肤细胞中，角质形成细胞、黑素细胞、血管内皮细胞、成纤维细胞和淋巴管内皮细胞表现出更强的氧化应激反应和氧化解毒能力，而免疫细胞表现出较弱的氧化应激响应和解毒能力。在衰老过程中，角质形成细胞、成纤维细胞、巨噬细胞和血管内皮细胞的氧化应激反应和氧化解毒能力显著减弱。膜联蛋白A1（ANXA1）和载脂蛋白E（APOE）可能是影响皮肤衰老的关键氧化应激相关基因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.