Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study.

IF 2.6 4区医学 Q2 PHYSIOLOGY

Journal of Physiological Sciences Pub Date : 2023-10-12 DOI:10.1186/s12576-023-00880-6

Hiroshi Ito, Masanobu Ibaraki, Ryo Yamakuni, Motoharu Hakozaki, Naoyuki Ukon, Shiro Ishii, Kenji Fukushima, Hitoshi Kubo, Kazuhiro Takahashi

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引用次数: 0

Abstract

The regional differences in cerebral oxygen extraction fraction (OEF) in brain were investigated using positron emission tomography (PET) in detail with consideration of systemic errors in PET measurement estimated by simulation studies. The cerebral blood flow (CBF), cerebral blood volume (CBV), OEF, and cerebral metabolic rate of oxygen (CMRO₂) were measured on healthy men by PET with ¹⁵O-labeled gases. The OEF values in the pons and the parahippocampal gyrus were significantly smaller than in the other brain regions. The OEF value in the lateral side of the occipital cortex was largest among the cerebral cortical regions. Simulation studies have revealed that errors in OEF caused by regional differences in the distribution volume of ¹⁵O-labeled water, as well as errors in OEF caused by a mixture of gray and white matter, must be negligible. The regional differences in OEF in brain must exist which might be related to physiological meanings.Article title: Kindly check and confirm the edit made in the article title.I have checked the article title and it is OK as is. Trial registration: The UMIN clinical trial number: UMIN000033382, https://www.umin.ac.jp/ctr/index.htm.

查看原文本刊更多论文

人类大脑中的氧气提取率并不均匀：正电子发射断层扫描研究。

考虑到模拟研究估计的PET测量中的系统误差，使用正电子发射断层扫描（PET）详细研究了大脑中大脑氧提取分数（OEF）的区域差异。用15O标记气体PET测量健康男性的脑血流量（CBF）、脑血容量（CBV）、OEF和脑氧代谢率（CMRO2）。脑桥和海马旁回的OEF值明显小于其他脑区。枕皮质外侧的OEF值在大脑皮质区域中最大。模拟研究表明，由15O标记水分布体积的区域差异引起的OEF误差，以及由灰质和白质混合物引起的OEF。脑组织中OEF的区域差异必然存在，这可能与生理意义有关。文章标题：请检查并确认文章标题中的编辑。我已经检查了文章标题，它是可以的。试验注册：UMIN临床试验编号：UMIN000033382，https://www.umin.ac.jp/ctr/index.htm.

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来源期刊

Journal of Physiological Sciences 医学-生理学

CiteScore

4.40

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.