Association between household cleaning product exposure in infancy and development of recurrent wheeze and asthma.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2023-12-01 Epub Date: 2023-10-11 DOI:10.1007/s00420-023-02011-5

Isis F Baroni, Geneva D Mehta, Ashley F Sullivan, Carlos A Camargo, Orianne Dumas

{"title":"Association between household cleaning product exposure in infancy and development of recurrent wheeze and asthma.","authors":"Isis F Baroni, Geneva D Mehta, Ashley F Sullivan, Carlos A Camargo, Orianne Dumas","doi":"10.1007/s00420-023-02011-5","DOIUrl":null,"url":null,"abstract":"Objective: Household chemicals may act as irritants in the lungs; however, their association with recurrent wheeze and asthma in children remains controversial. We aimed to investigate if household cleaning product exposure in infancy is associated with recurrent wheezing and asthma development in children.Methods: We analyzed data from two cohorts: MARC-35 consisting of 815 children with history of severe bronchiolitis in infancy, and MARC-43 consisting of 525 healthy children in infancy. Frequency of use of cleaning product at the child's home during infancy was collected via telephone interview with parents. Outcomes were recurrent wheezing by age 3 years and asthma diagnosis at age 6 years.Results: In MARC-35, there was no association between cleaning product exposure in infancy and recurrent wheeze (adjusted HR = 1.01 [95% CI 0.66-1.54] for 4-7 days/week exposure frequency), nor asthma (adjusted OR = 0.91 [95% CI 0.51-1.63]). In MARC-43, there was also no association between cleaning product exposure in infancy and recurrent wheeze (adjusted HR = 0.69 [95% CI 0.29-1.67] for 4-7 days/week exposure frequency).Conclusion: We found no association between household cleaning product exposure in infancy and later development of recurrent wheeze or asthma, even among children who are at high risk for asthma due to history of severe bronchiolitis.","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Archives of Occupational and Environmental Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00420-023-02011-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/11 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Household chemicals may act as irritants in the lungs; however, their association with recurrent wheeze and asthma in children remains controversial. We aimed to investigate if household cleaning product exposure in infancy is associated with recurrent wheezing and asthma development in children.

Methods: We analyzed data from two cohorts: MARC-35 consisting of 815 children with history of severe bronchiolitis in infancy, and MARC-43 consisting of 525 healthy children in infancy. Frequency of use of cleaning product at the child's home during infancy was collected via telephone interview with parents. Outcomes were recurrent wheezing by age 3 years and asthma diagnosis at age 6 years.

Results: In MARC-35, there was no association between cleaning product exposure in infancy and recurrent wheeze (adjusted HR = 1.01 [95% CI 0.66-1.54] for 4-7 days/week exposure frequency), nor asthma (adjusted OR = 0.91 [95% CI 0.51-1.63]). In MARC-43, there was also no association between cleaning product exposure in infancy and recurrent wheeze (adjusted HR = 0.69 [95% CI 0.29-1.67] for 4-7 days/week exposure frequency).

Conclusion: We found no association between household cleaning product exposure in infancy and later development of recurrent wheeze or asthma, even among children who are at high risk for asthma due to history of severe bronchiolitis.

查看原文本刊更多论文

婴儿期接触家用清洁产品与复发性喘息和哮喘发展之间的关系。

目的：家用化学品可能对肺部起刺激作用；然而，它们与儿童反复喘息和哮喘的关系仍然存在争议。我们旨在调查婴儿期接触家用清洁产品是否与儿童反复喘息和哮喘发展有关。方法：我们分析了来自两个队列的数据：MARC-35由815名婴儿期有严重细支气管炎病史的儿童组成，MARC-43由525名婴儿期健康儿童组成。通过与父母的电话访谈，收集婴儿期在家中使用清洁产品的频率。结果：在MARC-35中，婴儿期接触清洁产品与复发性喘息之间没有关联（调整HR = 1.01[95%CI 0.66-1.54]，暴露频率4-7天/周），也没有哮喘（调整OR = 0.91[95%CI 0.51-1.63]）。在MARC-43中，婴儿期接触清洁产品与复发性喘息之间也没有关联（调整HR = 0.69[95%CI 0.29-1.67]，暴露频率4-7天/周）。结论：我们发现婴儿期家庭清洁产品暴露与后来复发性喘息或哮喘的发展之间没有关联，即使在因严重细支气管炎病史而有哮喘高风险的儿童中也是如此。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.