Low 25-Hydroxyvitamin D [25(OH)D] Levels as a Predictor of Depressive Symptoms: Evidence from Community-Dwelling Older Adults Population in Mexico City.

IF 1.4 4区医学 Q4 GERIATRICS & GERONTOLOGY

Experimental Aging Research Pub Date : 2023-10-13 DOI:10.1080/0361073X.2023.2269803

Graciela Llanos-Becerra, Eduardo Dávila-Godínez, Norma Torres-Carrillo, Oscar Rosas-Carrasco, Elena Sandoval-Pinto, Raúl Beltrán-Ramírez, Nora Magdalena Torres-Carrillo

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引用次数: 0

Abstract

Objective: The purpose of this study was to assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels and depressive symptoms in Mexican older adults 70 years and older.

Methods: A total of 326 adults aged 70 or older from Coyoacán Cohort Study were included in this study. The depressive symptoms were assessing by Center for Epidemiologic Studies Depression Scale (CES-D) and serum 25-hydroxyvitamin D [25(OH)D] levels were measured by commercially available enzyme-linked immunosorbent assay (ELISA).

Results: Overall, the prevalence of depressive symptoms was 36.5%. The mean age was 79 years, and 53.4% were women. The total serum 25-hydroxyvitamin D [25(OH)D] levels were lower in older adults with depressive symptoms when compared with older adults without depressive symptoms (p = .006). Logistic regression models showed a significant association between low serum 25(OH)D levels and depressive symptoms even after adjusting for potential confounders (OR = 2.453; 95% CI:1.218-4.939; p = .012). In addition, linear regression model to predict the effect of 25-hydroxyvitamin D [25(OH)D] levels on the CES-D score as a continuous variable, was statistically significant [F_(1,324) = 8.54, p = .004], and the R-squared value was .026, indicating that this regression model explains 2.6% of the change in the CES-D score.

Conclusion: These results suggest that older Mexican adults with lower serum 25-hydroxyvitamin D [25(OH)D] levels are at higher risk of presenting depressive symptoms.

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低25-羟基维生素D[25（OH）D]水平作为抑郁症状的预测因素：来自墨西哥城社区居住老年人的证据。

目的：本研究的目的是评估墨西哥70岁老年人血清25-羟基维生素D[25（OH）D]水平与抑郁症状之间的关系年及以上。方法：本研究共纳入326名来自Coyoacán队列研究的70岁或以上成年人。抑郁症状通过流行病学研究中心抑郁量表（CES-D）进行评估，血清25-羟基维生素D[25（OH）D]水平通过市售酶联免疫吸附试验（ELISA）进行测量。结果：总体而言，抑郁症状的患病率为36.5%。平均年龄为79岁女性占53.4%。有抑郁症状的老年人血清25-羟基维生素D[25（OH）D]总水平低于没有抑郁症状的老人（p = .006）。Logistic回归模型显示，即使在调整了潜在的混杂因素（OR = 2.453；95%置信区间：1.218-4.939；p = .012）。此外，作为一个连续变量，预测25-羟基维生素D[25（OH）D]水平对CES-D评分的影响的线性回归模型具有统计学意义[F（1324） = 8.54，p = .004]，R平方值为.026，表明该回归模型解释了CES-D评分2.6%的变化。结论：这些结果表明，血清25-羟基维生素D[25（OH）D]水平较低的墨西哥老年人出现抑郁症状的风险较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Aging Research 医学-老年医学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.