Intermittent fasting in health and disease.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2023-10-13 DOI:10.1080/13813455.2023.2268301

Anubhav Mishra, Devika Sobha, Dimple Patel, Padmanaban S Suresh

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引用次数: 1

Abstract

Context: Intermittent fasting, a new-age dietary concept derived from an age-old tradition, involves repetitive cycles of fasting/calorie restriction and eating.

Objective: We aim to take a deep dive into the biological responses to intermittent fasting, delineate the disease-modifying and cognitive effects of intermittent fasting, and also shed light on the possible side effects.

Methods: Numerous in vitro and in vivo studies were reviewed, followed by an in-depth analysis, and compilation of their implications in health and disease.

Results: Intermittent fasting improves the body's stress tolerance, which is further amplified with exercise. It impacts various pathological conditions like cancer, obesity, diabetes, cardiovascular disease, and neurodegenerative diseases.

Conclusion: During dietary restriction, the human body experiences a metabolic switch due to the depletion of liver glycogen, which promotes a shift towards utilising fatty acids and ketones in the system, thereby significantly impacting adiposity, ageing and the immune response to various diseases.

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健康和疾病方面的间歇性禁食。

背景：间歇性禁食是一种源自古老传统的新时代饮食概念，涉及禁食/热量限制和饮食的重复循环。目的：我们旨在深入研究间歇性禁食的生物学反应，描述间歇性禁食对疾病的改善和认知影响，并阐明可能的副作用。方法：回顾了大量的体外和体内研究，然后对其在健康和疾病中的意义进行了深入分析和汇编。结果：间歇性禁食可以提高身体的应激耐受能力，而运动会进一步增强这种能力。它影响各种病理状况，如癌症、肥胖、糖尿病、心血管疾病和神经退行性疾病。结论：在饮食限制期间，由于肝糖原的消耗，人体经历了代谢转换，这促进了系统中脂肪酸和酮的利用，从而显著影响肥胖、衰老和对各种疾病的免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.

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