A survey of total IgE reference intervals reported by Scandinavian and British medical laboratories - a need for harmonisation.

IF 1.3 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI:10.1080/00365513.2023.2261102

Erik Wilhelm Vinnes, Ida Sofie Karlsen Sletten, Marie Alnæs, Torgeir Storaas, Aasne K Aarsand

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引用次数: 0

Abstract

Objectives: There appears to be marked discrepancies between total IgE reference intervals (RIs) in use by many laboratories and those recommended by published studies. The aim of this study was therefore to review total IgE RIs currently reported by Scandinavian and British laboratories and to compare these to published RIs identified by a literature review.

Methods: Relevant laboratories were identified by test directories provided by the national accreditation bodies in Norway, Sweden, Denmark and the UK. Total IgE RIs and their sources were acquired by accessing laboratory user handbooks or by an electronic survey. In addition a literature review of published total IgE RI studies was performed.

Results: From 172 accredited laboratories providing total IgE analysis, data was acquired from 122 laboratories. An adult upper reference limit between 81 to 150 kU/L was reported by 89% of these. Denmark and Sweden reported the most harmonised RIs whilst Norway and the UK exhibited the least degree of harmonisation. Published adult (n = 6) and paediatric (n = 6) RI studies reported markedly higher upper limits than those currently in use by the laboratories included in this study. There were also large variations in the number of age strata in use for paediatric RIs.

Conclusion: This study demonstrates large variations in currently utilised IgE RIs by Scandinavian and British accredited laboratories and most report markedly lower RIs than those recommended by recent RI publications. Many laboratories likely utilise outdated RIs and should consider critically reviewing and updating their RIs.

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斯堪的纳维亚和英国医学实验室报告的总IgE参考区间调查——需要协调。

目的：许多实验室使用的总IgE参考区间（RIs）与已发表的研究建议的总IgE参考区间之间似乎存在显著差异。因此，本研究的目的是审查斯堪的纳维亚和英国实验室目前报告的总IgE RIs，并将其与文献综述中确定的已发表RIs进行比较。方法：通过挪威、瑞典、丹麦和英国国家认证机构提供的测试目录确定相关实验室。通过查阅实验室用户手册或电子调查获取总IgE RIs及其来源。此外，还对已发表的总IgE RI研究进行了文献综述。结果：从172个提供总IgE分析的认证实验室中，从122个实验室获得了数据。其中89%的人报告了81至150kU/L之间的成人参考上限。丹麦和瑞典报告的RIs最为协调，而挪威和英国的协调程度最低。出版成人（n = 6）和儿科（n = 6） RI研究报告的上限明显高于本研究中实验室目前使用的上限。儿科RIs使用的年龄层数量也存在很大差异。结论：这项研究表明，斯堪的纳维亚和英国认可的实验室目前使用的IgE RIs存在很大差异，大多数报告的RIs明显低于最近RI出版物推荐的RIs。许多实验室可能使用过时的RIs，应考虑严格审查和更新其RIs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Clinical & Laboratory Investigation 医学-医学：研究与实验

CiteScore

3.50

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： The Scandinavian Journal of Clinical and Laboratory Investigation is an international scientific journal covering clinically oriented biochemical and physiological research. Since the launch of the journal in 1949, it has been a forum for international laboratory medicine, closely related to, and edited by, The Scandinavian Society for Clinical Chemistry. The journal contains peer-reviewed articles, editorials, invited reviews, and short technical notes, as well as several supplements each year. Supplements consist of monographs, and symposium and congress reports covering subjects within clinical chemistry and clinical physiology.